is a	snp
is	mentioned by
dbSNP	rs333
PheGenI	rs333
nextbio	rs333
hapmap	rs333
1000 genomes	rs333
hgdp	rs333
ensembl	rs333
gopubmed	rs333
geneview	rs333
scholar	rs333
google	rs333
pharmgkb	rs333
gwascentral	rs333
openSNP	rs333
23andMe	rs333
23andMe all	rs333
SNP Nexus
SNPshot	rs333
SNPdbe	rs333
MSV3d	rs333

Gene

CCR5

Chromosome

3

Orientation

plus

Position

46414947

Reference

GRCh37 37.1/131

Max Magnitude

4

Geno	Mag	Summary
(-;-)	4	very resistant to HIV
(-;GTCAGTATCAATTCTGGAAGAATTTCCAGACA)	2	resistant to HIV
(GTCAGTATCAATTCTGGAAGAATTTCCAGACA;GTCAGTATCAATTCTGGAAGAATTTCCAGACA)	0	common form

The chemokine receptor gene CCR5 plays an important role in many immune-related processes. Delta 32 rs333, designating the CCR5-delta32 deletion of 32 nucleotides from within the gene, is perhaps the most famous allele of CCR5. 23andMe tests for this by the name I3003626.

Individuals carrying one copy of the delta 32 allele are somewhat resistant to infection by HIV, the virus that causes AIDS, and individuals with 2 copies (delta 32 homozygotes, ~1% of Caucasians) are almost completely immune to infection by HIV. [PMID 8898752] The delta 32 allele may have been selected for in European populations because it confers resistance to plague (Black Death) or smallpox. [1]