Science

Hi everyone. I didn't see this mentioned here before.     http://www.theguardian.com/science/2013/dec/20/anti-ageing-human-trials  http://www.ncbi.nlm.nih.gov/pubmed/24360282    Mice were administered a NADH precursor, and it reversed physical ageing.   Think of a 60 year old taking the drug and his body will be like 20 again   (well, not toally because of aged proteins in the face, skin folds, etc.   but functional 20 year old :D )     I haven't found out yet whether feeding it would be sufficient (such a   small moleczule should be absorbed through the intestine, right?)  or if   you have to inject it into one's blood stream.   I remember seeing NADH pills in the drug store some time ago, and thought   "what is it good for? body building?"  

There are also experiments where they placed naked GFP with a promoter
in the nasal cavity of a mouse, later they saw the liver fluorescing.
The reference evades me now.

This Jove video also shows the tattooing of a mouse with GFP, but they
seem to have sectioned the tissue later, so it doesn't mention
necrosis, etc...
http://www.jove.com/video/50032/skin-tattooing-as-a-novel-approach-for-dna-vaccine-delivery

full video:
http://ecsource.jove.com/CDNSource/50032_ASV_082612_Web.mov


On Tue, Dec 31, 2013 at 11:00 AM, Cathal Garvey (Phone)
<cathalgarvey@cathalgarvey.me> wrote:
> Also, I have seen a phonecam shot of an alleged GFP "tattoo" where someone
> jabbed themselves with an Adenoviral gfp vector. I say "Alleged" because I
> can't imagine that working for more than an hour or so before going necrotic
> from immune rejection.
>
>
> Nathan McCorkle <nmz787@gmail.com> wrote:
>>
>>
>> On Dec 30, 2013 10:10 PM, "Patrik D&apos;haeseleer" <patrikd@gmail.com>
>> wrote:
>> >I bet it's only a matter of time before someone tries to give themselves
>> > a GFP tattoo with a gene gun though...
>> >
>>
>> That's already started happening, at least academically:
>> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855251/
>
>
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--
-Nathan

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Also, I have seen a phonecam shot of an alleged GFP "tattoo" where someone jabbed themselves with an Adenoviral gfp vector. I say "Alleged" because I can't imagine that working for more than an hour or so before going necrotic from immune rejection.

On Dec 30, 2013 10:10 PM, "Patrik D&apos;haeseleer" <patrikd@gmail.com> wrote:
>I bet it's only a matter of time before someone tries to give themselves a GFP tattoo with a gene gun though...
>

That's already started happening, at least academically:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855251/

You might want to ask a biosafety expert first.

Legalities of this idea are problematical, ethics are questionable..biosafety issues arw imediately applicable and I would guess anyone who had access to the technology wouldn't be granting access.
How would you prevent it infecting others? Could you cause yourself cancer?

Since I posted on this short fundraising initiative last month, I
thought I should let the group know that the goal was achieved in the
last couple of days. The community succeeded in raising $60,000 for the
SENS Research Foundation to help expand their work on various forms of
cellular and molecular damage repair technologies, aimed at reversing
the causes of aging per the SENS outline - which I'm sure you're all
familiar with.

Thank you to all who donated, and note that there is another matching
grant put up by Michael Cooper for the next $15,000 in donations to this
very worthy cause.

--------------------

https://www.fightaging.org/archives/2013/12/fundraising-success-60000-raised-for-rejuvenation-science-another-15000-matching-grant-announced.php

For the past month Fight Aging!, Jason Hope, and the Methuselah
Foundation have been running a 3 to 1 match on up to $15,000 donated to
the SENS Research Foundation before the end of the year. The Foundation
is perhaps the only organization in the world presently working
earnestly and seriously on the scientific foundations needed to produce
actual, real, working rejuvenation therapies, piece by piece over the
next few decades. The Foundation is very well connected in the research
community, funds projects in labs around the world, and the scientific
advisory board is made up of well-regarded names from numerous fields in
the life sciences and medicine.

It is the grassroots that drives the growth of any organization: the
more people that show support the easier it becomes to win large
investments from conservative funding sources and philanthropists.
Multi-million dollar donations for medical research only happen when
thousands of people make it known that this cause is worth it by giving
a little each. Thus more money raised and more supporters raising their
voices at this comparatively early juncture will lead to accelerating
progress over the years ahead, moving us towards the large-scale funding
needed for the best practical rate of growth in this field of research.
None of us are getting any younger, after all, and time is of the essence.

I'm very pleased to say that even after past months of generous
donations to fund a number of projects relating to healthy life
extension and research, the community still pulled together to find the
full $15,000 in just a few weeks, pulling in the combined $45,000 in
matching funds from Fight Aging!, Jason Hope, and the Methuselah Foundation.

But that isn't all: long-time Methuselah Foundation donor Michael Cooper
has put up another $15,000 matching fund that has yet to be met. Further
donations will be matched by this - so if you are still on the fence or
late to the news, here is your chance.

-----------------------

Reason

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Hello,

Hope you are doing well
Please go through the following requirement and please let me know on recruiter@tcagroupmail.com if you have any available candidates

Role: Project Manager with Sharepoint
Location: Brooklyn NY

SCOPE OF SERVICES 

Project Manager (ITCS)

·         Responsible for the completion of the specific phase of SharePoint upgrade. Each Phase requires a resource loaded project plan and work products that the Project Manager drives to completion.

·         Responsible for developing and maintaining project plans that are resource balanced and accurately depict resources need.

·         Maintain and escalate risks associated with the upgrade and migration. Manage all risks to completion.

·         Forecast critical path for upgrade and maintain project plan base lined dates.

·         Coordinate resources needed for successful completion of relevant SharePoint upgrade and migration phases.

MANDATORY SKILLS/EXPERIENCE

• Minimum of  8 years of IT Project Management experience
• 5 years' experience in designing multi-tier technology solutions

DESIRABLE SKILLS/EXPERIENCE:

• Familiarity with load balancing, firewalls, Microsoft TMG
• Knowledge of SharePoint 2010, SQL 2008/2012

Thanks,
Shalin
TCA Consulting Group
recruiter@tcagroupmail.com

I am not exactly sure what kind of insulation you are looking for. Typically any foam material works great, as long as it is able to withstand the heat.

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Hello,

Hope you are doing well
Please go through the following requirement and please let me know on recruiter@tcagroupmail.com if you have any available candidates

Role : Sr. QA
Location : Brooklyn NY

SCOPE OF SERVICES

The City of New York Department of Information Technology (DoITT) is implementing applications and reporting systems in support of the NYC housing recovery programs.  These programs are designed to help people directly affected by Superstorm Sandy achieve permanent, sustainable housing solutions.  This solicitation is for assistance with developing data sharing, analytics and reporting.  The scope of services to be performed by the selected individual includes:

• Work closely under the direction of the Project Manager and Technology manager with stakeholders from DoITT, the Mayor's Office and other city agencies including managers, line employees, and IT staff.

·         Work closely with project managers and project team to provide testing timelines and status;

·         Based on the analysis of design document and requirements create test strategy;

·         Design test plans for projects and work with project teams to obtain approval;

·         Work closely with project teams to understand solution requirements and generate test scripts and perform test analysis;

·         Execute all functional and performance tests according to test plans and scripts, document results, and quickly identify and troubleshoot issues;

·         Report the results to the management and team lead in timely matter

·         Other related development tasks in the SDLC

MANDATORY SKILLS / EXPERIENCE:

• At least 8 years of experience as a QA/Test team member;
• Programming experience and ability to program in Object Oriented or Procedural Languages is a must.
• Strong knowledge and ability to create complex SQL queries and work with SQL editors
• Fundamentals of MQ
• Ability to work with and validate Data Dictionaries
• Strong knowledge about XML file structure, XML schema, and XML file data validation.
• Experience in performance test of back end systems
• Must be able to understand requirements and translate them into test cases
• Ability to create quality assurance plans based on the analysis of design documents and requirements, Create and execute test cases, log and assign defects and keep track of the defect status
• Hands-on experience using tools like XML Spy, Perfmon, and Test Director/Quality Center.
• Understanding of a variety of programming languages, architectures, and standards (e.g., J2EE-Java, n-tier architecture, service oriented architecture)
• Must be able to see tasks through to completion with minimal guidance
• Ability to work independently in time sensitive environment and be fully responsible for work results
• Excellent oral and written communication skills and the ability to clearly articulate to all project members and stakeholders; must be a team player who works well with technical and non-technical resources;

DESIRABLE SKILLS/EXPERIENCE :

o    A Bachelor's degree in Computer Science, or Mathematics is desired;

o   Experienced with formal SDLCs and business analysis methodologies; Working knowledge of business analysis documentation standards;

o   Prior government project experience (NYC strongly preferred).

o   Familiarity with the data integration and exchange concepts

o   Familiarity with NIEM mapping and schema development

o   Prior software development experience in Java or .Net

Thanks,
Shalin