Science

ooo I love the story of Rapamycin and always start any talks around natural products with it.  In 1972 a group from Wyeth Brazil went to Easter Island and took soil samples from the edge of the extinct volcano there.  Originally Streptomyces hygroscopicus had a bio-active being pursued for anti-fungal properties.  Turns out it was an amazing immune suppressant (I do not know how this was tested).  Rapamycin, named after the native people's name for the island, Rapa Nui, is still used today to coat heart stents and after organ transplantation.  

The molecule has 15 chiral centers, and if you do 2^15 there are 32,768 unique isomers.   And a little microbe, eating decaying organic matter, with some oxygen, beautifully synthesizes an amazingly active molecule which is a multi billion dollar life saving medicine. 

I've never heard about its anti aging uses, would like to hear more. 

On Thu, Feb 29, 2024 at 12:49 PM Daniel C. <dcrookston@gmail.com> wrote:

I am very interested in this list not being spammed with advertisements for quackery.

I especially like how you don't talk about rapamycin, the most effective anti-aging drug currently available, which is a generic medication and therefore not profitable.

On Thu, Feb 29, 2024 at 7:41 AM jadams grg.org <jadams@grg.org> wrote:

Members,

 

My name's Johnny Adams. 

 

I recently moved to Florida to be active in two initiatives that I believe have the greatest potential for biological age management and reversal:

• Yamanaka/OSK gene therapy to reset the epigenome.  A therapy is a few years away.
• A plasma project involving therapeutic plasma replacement, infusion and exchange

 

It will initially be available in Florida, then in other parts of the country.

 

More information:

https://www.aginginterventionfoundation.org/JohnnyAdamsPlasmaProjectSummary.pdf

 

Please contact me if you have any interest.

 

Johnny

1-949-922-9786 cell

JAdams@AgingInterventionFoundation.org

 

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I am very interested in this list not being spammed with advertisements for quackery.

I especially like how you don't talk about rapamycin, the most effective anti-aging drug currently available, which is a generic medication and therefore not profitable.

On Thu, Feb 29, 2024 at 7:41 AM jadams grg.org <jadams@grg.org> wrote:

Members,

 

My name's Johnny Adams. 

 

I recently moved to Florida to be active in two initiatives that I believe have the greatest potential for biological age management and reversal:

• Yamanaka/OSK gene therapy to reset the epigenome.  A therapy is a few years away.
• A plasma project involving therapeutic plasma replacement, infusion and exchange

 

It will initially be available in Florida, then in other parts of the country.

 

More information:

https://www.aginginterventionfoundation.org/JohnnyAdamsPlasmaProjectSummary.pdf

 

Please contact me if you have any interest.

 

Johnny

1-949-922-9786 cell

JAdams@AgingInterventionFoundation.org

 

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Members,

 

My name's Johnny Adams. 

 

I recently moved to Florida to be active in two initiatives that I believe have the greatest potential for biological age management and reversal:

• Yamanaka/OSK gene therapy to reset the epigenome.  A therapy is a few years away.
• A plasma project involving therapeutic plasma replacement, infusion and exchange

 

It will initially be available in Florida, then in other parts of the country.

 

More information:

https://www.aginginterventionfoundation.org/JohnnyAdamsPlasmaProjectSummary.pdf

 

Please contact me if you have any interest.

 

Johnny

1-949-922-9786 cell

JAdams@AgingInterventionFoundation.org

 

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Does anyone know where these DIY groups are in the  Facebook, Reddit, Discords space? I feel like DIYbio has mostly died off compared to what it was in 2010s, but I'm hoping I'm just out of touch.

On Wed, Feb 28, 2024 at 11:01 AM Dan Kolis <dank...@gmail.com> wrote:

The VC world is plenty happy to convert nutrients to H20 + Urea on a huge scale. I mean, 'hunt the unicorn', then wait for layoffs due to nothing usable seems like a common plan.

 Again in the investment lingo; it is just 'widows and orphans' or do institutions fund endless go nowhere biotech, or what ? I don't know, I have tried to find out, and I am a little interested.

Like here in Toronto, the teachers Union has thrown in on Quantum computers FOR LIFE SCI, and the Fed and province peeled off millions for little analog computers that do exactly nothing, all blessed with urges based on Stat trek. I mean, That twisty thing on the screen, is that REAL DNA ?". How hard could this be ? Only took 45 seconds for Warf and some hottie to make a cure via an air blown med. Works first time perfectly, before the next commercial !

Ok. DIY or institutional, non-profit or whatever. Doing what took mother nature 100K years to do before a patent runs out, is not too easy.

Scale up a hobby, scale down a unicorn. Not so easy. When one atom in a molecule changes hugely what happens, its pretty tough stuff to tame.

regs,

Daniel B. Kolis

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-Hans T. Wilms
Cell: 404-322-5824

Noted :
" Reading two books recently: "Open-source lab" by Joshua Pearce and
                            "Building open source hardware" by Alicia Gibb"

I read the entries to "Dead or what" pretty carefully and didn't really light up with any specific conjectures except maybe to read / get / etc the books above...

Maybe there are some good animals extinct just the right amount and aren't taken yet by Harvard ?

You would think pollution abatement might work to getting investments ? Chem companies; like BASF, etc. 

Of course, most Bio projects fail horribly. That's a pretty basic fact, there...

Regs to All,

Dan