Re: [DIYbio] what's mucostasis?

Sounds about right. In normal lungs, mucous is secreted, mops up dirt, then gets shoved up into the oesophagus to be swallowed. In CS, it's too thick to be moved efficiently and biofilms can start to form, making it even more static and damaging lung structure.

Nathan McCorkle <nmz787@gmail.com> wrote:
first thoughts:
muco (having to do with mucus or the membranes)
stasis - 'standing still'

in CF the mucous is too thick from weird/unnormal ion concentration,
something like it doesn't move enough and doesn't mix around, limiting
oxygen to get across into/past cells by diffusion alone. I remember
some kid in a video on CF I saw, pounding his chest every morning
repeatedly.

http://www.youtube.com/watch?feature=player_detailpage&v=iLOL2WYD6SQ#t=171s

On Fri, Jun 21, 2013 at 7:46 PM, Jeswin <phillyj101@gmail.com> wrote:
Anyone explain to me what mucostasis means? The google search doesn't give
me much info. The context is in cystic fibrosis and the mucus clogging the
airways:

"As a consequence, increased water reabsorption across airway epithelial
cells leads to extreme dehydration of the
airway surface liquid layer, chronic mucostasis, and airflow obstruction."

Can read the whole article here:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356721/pdf/TSWJ2012-465230.pdf


Thanks

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