Re: [DIYbio] Re: Requesting your thoughts on a yogurt-based nutraceutical platform

On Mon, Oct 7, 2013 at 8:40 PM, Richard Yu <ryu@radiantgenomics.com> wrote:
> Hi Patrick-
>
> Thanks so much for your support!
> Good points. I don't know how Lacto will differ from Ecoli in terms of
> expresion of active C4H, or what the flux will be like in Lacto. We're
> hoping to stick with the simple things- expression levels, perhaps protein
> fusions might also do the trick (analogous to (Zhang, Y et al, JACS
> 128:13030-13031 (2006))). Fusing PAL to C4H, or C4h to 4CL? Get that
> substrate channeling thing going. The farther we get away from native
> proteins, though, the farther we get away from that food-grade criteria for
> a food product. It's an interesting set of scientific and non-scientific
> constraints to match :). Will be fun to see how far we can bring standard
> metabolic engineering and strain improvement techniques into the fold, too.
> (mutagenesis and selection, for example- not GMO!).

Realistically though that logic doesn't make sense. Is it possible to
not play that card in the marketing department? It just allows
ignorant unscientific claims to claim traction via your teams hard
work and sweat. Please, whatever you do, don't ever allow people to
think GMO is any worse or better than mutational or selective
breeding.

Microarray analyses reveal that plant mutagenesis may induce more
transcriptomic changes than transgene insertion
"Finally, we believe that safety assessment of improved plant
varieties should be carried out on a case-by-case basis and not simply
restricted to foods obtained through genetic engineering."
http://www.pnas.org/content/105/9/3640.full

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