[DIYbio] Re: How does/would sperm-based germline modification work?

New YACs are known to be highly unstable, which are actually why they started using BACs instead during the human genome project. I'd assume it'd be the same for a new human one.

Possibly use a viral system to excise the DNA in the presence of, lets say, lactose and tetracycline, but only when in germ line cells. 

On Friday, March 27, 2015 at 3:19:46 PM UTC-7, Nathan McCorkle wrote:
I've got an idea that you could make a condom-catheter type
microfluidic. I've read about male/female sorting of sperm, but how do
you edit the DNA? I know about CRISPR, transposons, and probably some
other similar things I can't remember, but any other ways that have
been thought of or experimented with?
Is adding a new chromosome a better idea? Would this prevent the 'new'
chromosome from being passed during future breeding with a
non-modified person? (I think that would make the neo-human less
offensive to anti-GMO folks)
Previously I've asked what political/social climate would be most
conducive to this work, and I think the answer was 'south korea', but
that was a few years ago, and I wonder if there's a better place these
days. Not necessarily a country with active research, but one that
would be supportive of active evolution, rather than being fearful?

--
-Nathan

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