I'm not into gene therapy field, but I did read this article a bit back when it first came out
-- http://www.nature.com/news/gene-editing-method-tackles-hiv-in-first-clinical-test-1.14813
http://www.ncbi.nlm.nih.gov/pubmed/24597865?dopt=Abstract&holding=npg
If my memory is correct, they use adeno-associated virus which integrates on chromosome 19 to express their zinc fingers. I don't exactly remember if they can turn off that expression though, but the immune system would most likely target the zinc fingers which may be a problem.
-Koeng
On Thursday, March 26, 2015 at 3:44:32 PM UTC-7, Cathal Garvey wrote:
On Thursday, March 26, 2015 at 3:44:32 PM UTC-7, Cathal Garvey wrote:
Truth on the hypothetical part; there's nothing wrong with imagining,
scoping, and simulating stuff, as long as you don't kill yourself
attempting it.
As far as the Cystic Fibrosis gene therapy, there's loads of work there
and possibly even some stuff in trials, but I have yet to hear about it
ever being approved for use.
The "success story" of gene therapy was the SCID kids whose
immunodeficiency was partially resolved with gene therapy, but I think
at least three of those 10 kids developed leukemia due to the therapy
afterwards. If I were them, I'd consider that a fair price paid, because
SCID is as likely to kill you as leukemia, but as a result gene therapy
for SCID is not (AFAIK) something that happens anymore. It's considered
a failed trial.
On 26/03/15 22:39, Mega [Andreas Stuermer] wrote:
> I think the gene therapy for cystic fibrosis was legal? Basically you inhale naked DNA into your lungs, some cells take it up and this is sufficient to cure the disease...
>
> Don't try gene therapy at home diy, at least if you express proteins it has high risks involved. siRNAs - there's hardly data om that but I would rather have professional labs design them and then hack them diy style than testing them in homo
> On a sidenote, if you follow a hypothetical project you can still learn a ton!
>
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