Re: [DIYbio] Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna

This is similar:
http://diyhpl.us/~nmz787/pdf/Structural_and_kinetic_effects_of_mobile_phone_microwaves_on_acetylcholinesterase_activity.pdf

On Mon, Jan 21, 2013 at 1:20 AM, Nathan McCorkle <nmz787@gmail.com> wrote:
> Looks like there are some terms like skin-depth I need to look up, but
> the DNA to gold nanoparticle coupling looks pretty easy, but it
> requires the DNA to be modified with an amine so this is only gonna
> work for synthetic oligos/genes.
>
> This paper shares some common language with the somewhat controversial
> DNA self-oscillation papers by Luc Montagnier
> http://montagnier.org/Electromagnetic-signals-DNA
>
> If we could compare the math in the two papers, and it checks out to
> be similar... maybe we can try the same melt-dissociation test that
> the gold paper uses, only with the plain DNAs calculated frequency.
> Their equipment setups aren't much different either, though they're
> using much different frequencies (7hz for Luc Montagnier's vs 1ghz for
> MIT's)
>
> On Sun, Jan 20, 2013 at 11:51 PM, Cathal Garvey (Phone)
> <cathalgarvey@cathalgarvey.me> wrote:
>> To what extent can this method differentiate between different molecules, I
>> wonder? As in, could they melt duplex A while leaving B alone, and then vice
>> versa a minute later?
>>
>> Fascinating method! Can it be easily DIY'd? :)
>>
>>
>> Nathan McCorkle <nmz787@gmail.com> wrote:
>>>
>>> Very cool stuff, no updates on their website since 2002 though :/
>>> http://www.media.mit.edu/molecular/
>>>
>>> Remote electronic control of DNA hybridization through inductive
>>> coupling to an attached metal nanocrystal antenna
>>> Kimberly Hamad-Schifferli, John J. Schwartz, Aaron T. Santos,Shuguang
>>> Zhang & Joseph M. Jacobson
>>>
>>> Increasingly detailed structural and dynamic studies are highlighting
>>> the precision with which biomolecules execute often complex tasks at
>>> the molecular scale. The ef®ciency and versatility of these processes
>>> have inspired many attempts to mimic or harness them. To date,
>>> biomolecules have been used to perform computational operations and
>>> actuation, to construct artifcial transcriptional loops that behave
>>> like simple circuit elements and to direct the assembly of
>>> nanocrystals. Further development of these approaches requires new
>>> tools for the physical and chemical manipulation of biological
>>> systems. Biomolecular activity has been triggered optically through
>>> the use of chromophores, but direct electronic control over
>>> biomolecular `machinery' in a speci®c and fully reversible manner has
>>> not yet been achieved. Here we demonstrate remote electronic control
>>> over the hybridization behaviour of DNA molecules, by inductive
>>> coupling of a radio-frequency magnetic ®eld to a metal nanocrystal
>>> covalently linked to DNA. Inductive coupling to the nano-crystal
>>> increases the local temperature of the bound DNA, thereby
>>> inducing denaturation while leaving surrounding molecules relatively
>>> unaffected. Moreover, because dissolved biomolecules dissipate heat in
>>> less than 50 picoseconds, the switching is fully reversible. Inductive
>>> heating of macroscopic samples is widely used, but the present
>>> approach should allow extension of this concept to the control of
>>> hybridization and thus of a broad range of biological functions on the
>>> molecular scale.
>>>
>>> http://www.media.mit.edu/molecular/HamadNature.pdf
>>>
>>
>> --
>> Sent from my Android phone with K-9 Mail. Please excuse my brevity.
>>
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>
>
>
> --
> -Nathan



--
-Nathan

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