Hi Richard,
Cheers,
I saw your Indiegogo the other day and was planning on getting in touch with you -- great to see you here!
A couple of iGEM students here in Brussels and I decided a few weeks ago to reboot the melaminometer project (openwetware.org/wiki/User:Jonathan_Cline/Notebook/Melaminometer), and we're in the process of rebuilding my lab (we're doing inventory as we speak, actually). My pipe-dream project, though, is to produce a strain of lactic acid bacteria that expresses L-gulonolactone oxidase, the last enzymatic step in the mammalian ascorbate synthesis pathway (the final step is spontaneous). Humans and guinea pigs only have a pseudogene for this enzyme, and so we can't make our own vitamin C. I'm not sure whether expression of GULO in the gut will restart the pathway (if not, then the next question is whether one of the full ascorbate synthesis pathways can be packed onto a plasmid), but that's the idea that got me into DIYbio in the first place.
What can you tell us about the plasmids you're using?
Cheers,
--mlp
On Thu, Oct 3, 2013 at 7:00 PM, Richard Yu <ryu@radiantgenomics.com> wrote:
Hi DIYbio,--I know many of you have thought quite a bit about hacking yogurt (L. bulgaricus, specifically), and I wanted to solicit your thoughts on a "20% time" fun project some friends of mine and I are pursuing at a natural products biotech startup (http://igg.me/at/yovivo)-Frameworks:We've chosen resveratrol yogurt as a POC/test project. We are actually serious about bringing this to food production stages, so in addition to the usual difficulties of biology of just getting it to work period, there are other issues we need to consider- FDA rules/regs surrounding eating a microbial GMO product, and how to actively engage with other communities that may not be so sympathetic to GMOs. Sure, many of us have a dream of having a milk-based platform for making whatever nutraceutical or med or glowing/fluorescent protein or smell or flavor- what are your concerns about such a platform? what do you think the general public's concerns might be?-Projects:Do you guys have thoughts on specific related projects that might be fun and important? This includes other products (we've gotten about a billion requests for frozen yogurt) or even fun projects we might do to engage with the DIYbio community, perhaps at a space like Biocurious? What are informative things that we can do, and how can we do them, so that won't needlessly fan the flames of anti-GMO sentiment and make our work and play harder?Thanks in advance for any thoughts!Best,Rich
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