Yep! That's what the cuvette in the video I linked to was made with. Spot size is limited by the CO2 laser's wavelength, 10.6 Microns, but also by how well manufactured the laser tube is within some exact integer value of the wavelength, any imperfect lenses or mirrors or focus adjustment. Average for these desktop laser cutters is 100-500 microns. Focusing is hard because you can't see the beam with your eyes, using a piece of heat sensitive receipt paper is how I've done it, they also sell reusable heat sensitive (liquid crystal filled?) Index card sized things, pretty cheap... Like a 'mood ring' sort of effect. Having the optical movement axes not perfectly parallel with the build surface could be an issue for larger devices.
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