On Tuesday, February 25, 2014 2:00:26 PM UTC-8, Cathal Garvey wrote:
If you could ship DNA at 1/100 the costs I pay, I wouldn't care if it
had a 1/1000 error rate. That'd probably be my threshold for
correctional PCR, but at 1/100 the cost I could easily afford sequencing
and a few primers to amend errors.
That's essentially my thought process. It may be far cheaper for us to manufacture tons of DNA strands in parallel with comparatively low accuracy, and then have some kind of QC mechanism right before output. We need some kind of nanomaterial that can keep things relatively in place long enough to read a strand AND destroy it if it is not what we wanted. Nanotubes, nanopores, nano-whatever. Anything that can be placed somewhat easily. I still like nanotubes more just because they are easy to align in small quantities using static fields. It's when things start getting larger than a few microns that the problems start to develop.
For me, DNA synth costs are a huge, huge factor in my ability to work,
so that'd be a huge change.
That's exactly my point. All of a sudden, making many iterations of a novel genome you are kind of shaky on becomes easier than doing painstaking research for years to try to find a way to do everything you want to do using known sequences. The R&D time for each novel organism (I'm talking simplified bacteria here, not like an oak tree) would drop from a decade to months. Maybe even weeks for a well-funded lab.
At this point, because of how cheap everything else would become as a result of having a DNA read/write chip, DNA synth costs are the limiting factor.
At this point, because of how cheap everything else would become as a result of having a DNA read/write chip, DNA synth costs are the limiting factor.
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