Re: [DIYbio] Re: Do cells of the same type in different species act differently with the same DNA?

http://www.genengnews.com/gen-news-highlights/stem-cells-created-by-cloning-get-mitochondrial-baggage-check/81250629/

Do cells of the same type in different species act differently with the same DNA?
Short answer? yes. At least they should if you modeled the donor cells to play by the same set of rules as the receiver.

You are probably asking these questions due to reading up on human brain cells in a mouse. Right?

Gauging the community?

Humanized pig and monkey organs and tissues come to mind when thinking about your question.

There could be a rejection as enucleated (donor cells without a nucleus) has a different mtDNA and when nucleated (with a receiver nucleus) can stand out against the background mtDNA setting, post auto grafting.

There were cases of snake genes sneaking into the bovine genome. I don't know about their expression in the bovine genome. Different codon usage, maybe even different intron usage. Definitely different mammalian tRNA usage in mitochondrion. Some of the aa deviates from the rest. Turns out your immune system can tell its mitochondria from non self mitochondria.

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