[DIYbio] Re: ily1 ily2 antibody ribosome system

Where do you get this hypothesis?  That's not how antibody molecules are created at all.

Any one B cell in the body makes one antibody protein.  There is a variable region in antibody molecules which differs between the individual B cells.  That variable region is highly diverse and pretty much random.  Antibodies have to be made well in advance of encountering the antigen, and the antigen cannot be known beforehand.  

Two implications follow from this process.  1) Many antibodies are made which are completely useless.  They will never encounter a matching antigen.  This is inefficient, but it's otherwise harmless.  2) Some antibodies are made which react with the proteins found in normal, healthy individuals.  These antibodies are potentially a problem: they can cause autoimmune disease.  In order to deal with this second problem, the body has a special organ where immature B cells are tested first to see if their antibodies react with healthy tissue.  This happens at the cell surface, not inside the cell at the ribosome.  In humans, the organ where this testing takes place is the spleen.  If an immature B cell is found to react with self, that cell is killed off instead of being allowed to mature, potentially divide, and spread throughout the body.