Re: [DIYbio] Is there an alternative open source software to COMSOL for modeling drug delivery/neuroregeneration?

Hello,

Interesting project you've chosen. Could you elaborate on what you mean by conduit?

If it's what I think it is: a small pathway that will deliver the drug to the specific locations at a desired rate, then I'll also assume that it has to be permeable at some point. But that will depend on if it is end point (just a tube that provides the medicine) or a semi-permeable membrane that will slowly deliver the drug.

End point would be easier, since you could just have a constant influx of medicine in one spot and attempt to model the diffusion of it in the skin using some sort of Stokes-Einstein diffusion equation where the 'tissue' has some average diffusion constant. You would have to convert it to a spherical coordinate system with a little bit of calculus (or you could just look up the right answer) but it's certainly possible.

The semi-permeable version is a little more elegant, giving a more full delivery of the medicine using only a single 'conduit', but the concentration of the medicine will decrease over time. Luckily that should be an easy variable to integrate into your system. This version would require converting to a cylindrical coordinate system, but like I said before: the information is already out there. Constructing it, may be more difficult.

Not sure if I helped.

-SG

On Thu, Dec 14, 2017 at 8:37 PM Nathan McCorkle <nmz787@gmail.com> wrote:
Over many years, I have been trying to slowly learn about fluid
dynamics and CFD and hoping to stick to open-source tools. I am
interested in nanofluidics and electrophoresis modelling.

Here are some links I collected, but have not repeated yet:
    https://en.wikiversity.org/wiki/CAD_to_FEniCS_example
    https://fenicsproject.org/pub/tutorial/html/._ftut1009.html#ftut1:NS

A list of software:
    https://cfdandheattransfer.wordpress.com/category/cfd-softwares/

I have a Python library to programmatically create 3D objects using BRL-CAD:
    https://github.com/nmz787/python-brlcad-tcl
which can export to at least:
    STL and image-slices (for i.e. lithography masks)

-Nathan

On Wed, Dec 13, 2017 at 8:41 PM, Samantha Kamath
<samanthakamath2000@gmail.com> wrote:
>However, COMSOL is expensive; does anybody know of an open source alternative to COMSOL that allows for a similar approach?

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