Re: [DIYbio] Re: Biosecurity

"They had that conversation, somewhat publicly, in the 1970s.  Why bring attention to something a second time that might make the public nervous and only hurt research progress and biotech profits?"

Have you ever heard the term "ISOLATED DEMANDS FOR RIGOR"?

They've had that conversation, they've repeated that conversation countless times. They've had it so many times that they roll their eyes every time someone brings it up because 99.999% of the time it's someone with no special insight bringing up "concerns" that don't even make sense or which aren't grounded in anything other than boundless paranoia. They are sick of the people who keep thinking they have anything of value to add to that conversation. Because those people do not.

There are scary things people could do.
I a few years it's likely small groups with modest funding will have the capacity to re-create smallpox or custom viruses.
The real risks aren't random accidents. The real risks are people intentionally setting out to create weapons.

We already create situations that would never exist in nature through selective pressures that could never exist without human intervention. And nobody bats and eye. But the moment it's "GMO's" suddenly it's all isolated demands for rigor.

It's argumentum ad ignorantiam.

Put another way. Lets imagine a non-GMO plant. (at least as far as regulators are concerned)

The farmer has a plantations of their crop growing... and they notice that the fruit from one of their plants is an unusual color.

When they taste it they notice that it's sweeter than normal.

The farmer does not know anything about genetics. He may not even know that genes are a thing that exist.

He doesn't know if the mutation that unregulated sugar production in the fruit and pigment production in the skin did something else.

For all he know's it could also have unregulated production of some carcinogenic compound in the flesh of the fruit.

Hell there could be some novel virus involved.

He has no idea. All he sees is a sweet fruit with an interesting color.

So he breeds from that plant or takes cuttings and grows more. And a few years later everyone is eating them. With no safety testing.

Thus is the "traditional", "organic" method.

There's something on the order of 40 "natural" pesticides in the flesh of an average carrot. Have they ever been through safety testing with higher concentrations? no.

That flashy new variety of carrot with extra sweet flesh that the local organic farmers are so keen on?

It's never been through safety testing. They don't know if the genetic change that caused the change in sweetness upregulated something else.

This isn't even a hypothetical. it's happened.

https://boingboing.net/2013/03/25/the-case-of-the-poison-potato.html

sometimes those all-natural organic crops, modified only by traditional breeding techniques yield something dangerous.

because on a fundamental level, on a real nuts and bolts level, the people creating those varieties have absolutely no idea why they're getting the results they're seeing. They have no idea what pathways have been modified. They're like cavemen modifying a car engine with a heavy rock.

There's even atomic gardening, take the crop you want to generate new "organic" varieties for, grow it in a field, put a big radiation source in the middle and zap the plants. Some will die and some will survive and some of the survivors will produce seeds with unusual traits.

But the farmer who sees a novel trait has no idea how it's working internally.For all he knows s it could be upregulating something that produces substances that cause brain damage in human children.

Meanwhile, with GMOs, the people making the change have spent years studying the exact genes they're changing, they've spent years studying the exact pathways involved and they're making exactly the precise change they intend to make.

So far "traditional", "organic" breeding techniques have yielded killer bees, grass that produces clouds of toxic cyanide in dry weather and potatos that can slowly kill you among other fuckups.

Meanwhile in 30+ years GMO's have yielded disasters such as.... and... and... hmmm.. nope, nothing.

So I don't buy the bullshit. GMO's are fundamentally safer because of how they're created.

If you find yourself declaring that it should all be moved to the moon: Stop talking because you're making everyone in the room dumber.


On Sat, May 25, 2019 at 1:44 AM Matt Endrizzi <matt.endrizzi@gmail.com> wrote:
Or George Church printing a coded copy of his book on a tiny piece of paper using DNA.  When Stephen Colbert tried to eat the paper, Dr. Church grabbed it from him.

Yes, awareness is as critical as following safety protocols. That is why I am reaching out to the DIYbio community - to check on this level of awareness.  Based on the few responses I have received so far, it seems there is a sentiment that the "Pros" are doing way worse stuff than us, so we don't have to worry about it.  Perhaps if the DIYbio community took the lead on communicating about safety of their own work, the general public might start to learn about risks associated with biotechnology. I have found, after 17 years of trying, that professionals using recombinant nucleic acids are not open to talking about this risk perspective anymore.  They had that conversation, somewhat publicly, in the 1970s.  Why bring attention to something a second time that might make the public nervous and only hurt research progress and biotech profits?

If the main purpose of DIYbio is to bring biotech to the masses and make it accessible to all, isn't public safety a good place to start?

Scientists by nature focus on speaking about what they have learned based on data and observations.  That is another reason trying to talk scientifically about the risks of recombinant nucleic acids is problematic.  The focus tends to be on human pathogens and related gene sequences that we know of.  The danger with following this line of thinking ONLY is that we can miss plausible threats that are right under our nose that we are not even contemplating might be risky.  It's a bit like some toddlers found dad's gun in the closet and are playing with it without anyone watching them.  I would apply this analogy to both the Pros and the DIYs.

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