Re: [DIYbio] Drug addiction biohacking

The "new cells" are the cells that have been altered via CRISPR to have whatever the new material you inserted. Existing neurons won't be affected. So while adult neurogenesis does happen, the maximum effect (assuming it even worked) is going to be restricted to newly grown cells.

That story doesn't link to any source material, but my guess it refers to a mutation that down regulates the expression of mu opioid receptors.  That makes it so the effective signal from the opioids reaches saturation at a level where the physiological effect is quite low. Such mutations are also correlated with increased likelihood to develop opiate addictions since individuals have to start off taking a much higher dose to feel the effect, even before habituation. The circuits relating to physical dependence, however, increase their sensitivity with additional exposure.

On Fri, Sep 20, 2019 at 3:19 PM jackson parks <jacksonpar...@gmail.com> wrote:

What exactly are these new nerve cells you speak of? Genetic engineering can enable us to grow new receptors and all that where they don't respond to xenobiotics? Here's an example of what I was referring to originally: https://norwegianscitechnews.com/2016/07/50000-norwegians-require-more-morphine-than-the-average-joe/  (Notice the part where it says, "And about a hundred people in Norway are completely resistant to opioids such as morphine.") What enables this to happen with the opioid receptors? It's a mutation, but can we genetically alter this in someone who never had this mutation to begin with? And what about other receptors as well, such as GABA, NMDA, dopamine receptors, etc?

On Thursday, September 19, 2019 at 9:23:39 PM UTC-4, louie anderson wrote:

Yeah so there's not really good ways that I know of to do this the whole reason the drugs work is because they look like (on a bio molecular level at least) like funky but still functional neurotransmitters, so.if you block your brain from susceptibility to them you also could potentially block it from it's own signals on top of the fact that if you do this via genetic egineering than only the new nerve cells will exhibit the traits you are looking for

On Thu, Sep 19, 2019, 15:29 jackson parks <jacksonpar...@gmail.com> wrote:

Thank you for the quick response. Yes, we're very familiar with dopamine blocking, but we're looking to experiment with something a little more radical than that. We're looking to see if the nervous system can be biohacked to prevent future benzodiazapine addictions for those looking for something that extreme. One idea is switching off the GABA receptor's capacity to allow xenobiotic agonists to bind to them. There are also other ways we're looking to do this with things like microwaves.

On Thursday, September 19, 2019 at 5:59:11 PM UTC-4, louie anderson wrote:

Hi Jack,

You should look into dopamine blocking therapies. They esstientially have people continue to do the action that they are addicted to, while on a drug that stops the release of dopamine and other feel good chemicals. It's proven very effective and with some tweaking like adding in a negative stimulus while on the dopamine blocking drug everytime they perform the action I think it could be a promiaing avenue for attacking addiction.

Best Wishes,

Louis J Anderson

On Thu, Sep 19, 2019, 14:40 jackson parks <jacksonpar...@gmail.com> wrote:

Hello,

Thank you for letting me in. I'm Jack. A friend of mine named Jonathyn recently quit the idea of engaging in CRISPR CAS9 technology because he found out that it can't do anything for adult humans. We've been trying to find a way to help people with drug addiction, and we got introduced to biohacking. We're interested in being able to change people's nervous systems either through microwave radiation (https://www.ncbi.nlm.nih.gov/pubmed/1312845), CRISPR (if it can do anything at all), or whatever other means that don't technically need surgical procedures.

Thank you all, Jack.

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