https://en.wikipedia.org/wiki/Raspberry_ketone
Raspberry ketone is sometimes used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. It is one of the most expensive natural flavor components used in the food industry. The natural compound can cost as much as $20,000 per kg.[5] Synthetic raspberry ketone is cheaper, with estimates ranging from a couple of dollars per pound[9] to one fifth of the cost of the natural product
Not beating a dead horse but that is an example of flavoring that's used a lot. It's the same chemical compound of course, but being made not in a test tube with synthesis means it can be marketed as "natural".
Plenty of high-value flavorings and fragrances I'm sure, and I know there are companies trying to make them with microbes as well.
There's also high value natural products, cancer drugs, etc - that are made by some really crazy chemistry in nature but that can't be done synthetically due to stereochemistry. The more chiral centers the more miserable the synthetic route.
Taxol/Paclitaxel is a good example, starting with Gary Strobel.
They used to legit harvest tree bark from a pacific yew and extract it, talk about a slow growing organism. Then Dr. Strobel found a fungal endophyte that produces the same compound. Now I believe it's done via plant-cell culture in reactors. https://en.wikipedia.org/wiki/Paclitaxel
An interesting journey following it though from bark to bioreactor.
There have been a few natural products I've stumbled across in reading but whose names escape me, that were given up on by pharma because they couldn't be produced at scale. One was from a marine tunicate I think...can't go rip up all the tunicates off this little island to make 1 compound. Sometimes they find those products are produced by endosymbiotic bacteria or fungi, but not always. Idk who is doing tunicate cell expression either, ha.
Another high-value biological is horse-shoe crab blood. LAL for ensuring medical devices are free from pyrogens. That's all off the top of my head. https://en.wikipedia.org/wiki/Limulus_amebocyte_lysate
On Wed, Jul 29, 2020 at 4:26 PM Jonathan Cline <jncline@gmail.com> wrote:
--https://www.theguardian.com/science/blog/2011/jun/21/scientists-make-lsd-from-microbesHint: it didnt work.
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