Re: [DIYbio] Continuous (blood) Analyte Monitoring

Everything is either an ELISA or ECLIA test as far as I know, with the
steroids also offering LC-MS/MS for higher sensitivity. I've done the
LC-MS/MS for estradiol as well as the normal ELISA and they were >110%
variation between the two readings. ELISA says my E2 is high, LCMS/MS
says it's mid-range and fine. Plenty of other compounds can interfere
with the enzyme linked assays. Would be pretty cool to have a
constant monitoring of hormones but I don't see those tests ever
miniaturizing anytime soon.

I'm not even sure how the CGM works, is it all conductance based? Some
electrical readout? Glucose is present at what, 100mg/mL? Those
hormones are present at levels of nanograms to picograms per 10mL.

On Fri, Apr 9, 2021 at 2:07 PM Tom De Medts <tdmedts@gmail.com> wrote:
>
> Dear all,
>
> Is there anyone with experience in designing and implementing Continuous (blood) Analyte Monitoring like the now commonly used Continuous Glucose Monitor (CGM)?
>
> My question for you is based out of my own experience and frustration at fertility treatments. My spouse's hormone profile is very different from the ideal case, and it would be nice to be able to monitor her natural cyclic fluctuation in female hormones such as
>
> Estradiol
> Follicle Stimulating Hormone
> Luteinizing Hormone
> Progesterone
>
> Online searches for continuous monitoring of these blood analytes were not available. Please note I am not referring to strip tests for use with pinprick blood tests or with urine samples. If I am wrong, and there are indeed continuous monitors for any of these hormones, please let us know.
>
> Else, if you have expertise / experience in any subject area(s) related to developing such CGM-like devices, could you please dumb it down for a non-technical audience and list
>
> what the low hanging fruits that could be easily achieved are
> what the biological challenges are
> what the tech challenges with measurements are
> and anything else...
>
>
> Thanks!
> Tom
>
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