Re: [DIYbio] Streaming platform for science

10:48 AM |


Points to the ongoing NSF notion for sharing metadata, etc.

https://datamanagement.hms.harvard.edu/plan-design/data-management-plans/nsf-data-management-and-sharing-plan#:~:text=What%20is%20required%3F,of%20work%20under%20NSF%20grants.

Note there are a few worked examples. As you may know;( ie USA researcher or assoc of it ) having this is worth some points in the funding number aggregation process, too...
 

 

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Posted by Science

Re: [DIYbio] Streaming platform for science

12:54 PM |

PeerTube


On Aug 21, 2024, at 12:27 PM, Dakota Hamill <dkotes@gmail.com> wrote:

Haha that's great.  I didn't mean to come off as a wet blanket.  Openly sharing is what it should be all about.  

Does anyone know the name of that free and open video protocol website that isn't JOVE?  

On Wed, Aug 21, 2024, 9:18 AM Hans Wilms <hanstwilms@gmail.com> wrote:
Thanks, Dan.

Dakota, I see what you're saying, but my PI specifically encouraged this. He has no plans to patent, and our field is more about working together than it is stealing ideas. Maybe we're just an exception though!

On Sat, Aug 17, 2024 at 12:39 PM Dakota Hamill <dkotes@gmail.com> wrote:
Always thought streaming science would be cool.  Then reality sets in.  That would probably kill any chance to patent or publish something.  Then your PI doesn't get a grant, then the University sues you, then you get fired.  

I'm being pessimistic but based on things I've seen and experienced, it's probably not far off.  

Someone's paying you to do that research presumably if you're at a University, and you're giving the results away for free and disclosing it to the public.  

I'm not saying that's the way it should be, but seems how it is. 

Jove is cool but paywalled.  

There used to be another more open video protocol website I forget the name of.  I thought it was like petri.com or experiment.com or labrat or bench something.  

On Sat, Aug 17, 2024, 11:47 AM Dan Kolis <dankolis@gmail.com> wrote:
Making real life science new knowledge shareable is really difficult. The amusing two steps done currently, are just morning kisses of blowing in the mirror of self adoration, really. This is pathetic, but its also important to realise really sharing heavy duty facts, newish systems and supporting ideas, S/W, Data on and on it goes is generally more labor and time then most research line items.

What are those sad two steps ?

1) Incoherent Github with almost no worked examples. No real enabling stuffola, whatsoever. 

2) Fat database and web browser program. One is unusable due to no metadata, the other just falls apart after a couple months.

Did I mention a snazzy name for whatever it isn't ?

Oh, that's 3 things, sorry.

Can this be improved ? Well, yes but its a field of low expectations here. I mean, downloading a massive TAR or ZIP file and poking at it for 1/2 hour, is very close to a worthless, but not entirely,. "Something in here might do something !", is about all the end user gets. Watching the alleged support s/w fall apart is pretty sad, too. 

 Low expectations ! That's the firster activation code here ? Maybe....

Face it entirely too: George Church says only a company to try each thing has the pull to matter.  So then the science urge is turned into greasy unfulfilled promises and the counting of unhatched chickens for the bean counters.

"Did you boys get paid anything, by anybody, this week ?" is the sudden, in your face every day question, not whether it really works at all; ( phooey on that noise ).


Regs
Daniel B. Kolis; 17Aug2024



 

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Posted by Science

Re: [DIYbio] Streaming platform for science

9:27 AM |

Haha that's great.  I didn't mean to come off as a wet blanket.  Openly sharing is what it should be all about.  

Does anyone know the name of that free and open video protocol website that isn't JOVE?  

On Wed, Aug 21, 2024, 9:18 AM Hans Wilms <hanstwilms@gmail.com> wrote:
Thanks, Dan.

Dakota, I see what you're saying, but my PI specifically encouraged this. He has no plans to patent, and our field is more about working together than it is stealing ideas. Maybe we're just an exception though!

On Sat, Aug 17, 2024 at 12:39 PM Dakota Hamill <dkotes@gmail.com> wrote:
Always thought streaming science would be cool.  Then reality sets in.  That would probably kill any chance to patent or publish something.  Then your PI doesn't get a grant, then the University sues you, then you get fired.  

I'm being pessimistic but based on things I've seen and experienced, it's probably not far off.  

Someone's paying you to do that research presumably if you're at a University, and you're giving the results away for free and disclosing it to the public.  

I'm not saying that's the way it should be, but seems how it is. 

Jove is cool but paywalled.  

There used to be another more open video protocol website I forget the name of.  I thought it was like petri.com or experiment.com or labrat or bench something.  

On Sat, Aug 17, 2024, 11:47 AM Dan Kolis <dankolis@gmail.com> wrote:
Making real life science new knowledge shareable is really difficult. The amusing two steps done currently, are just morning kisses of blowing in the mirror of self adoration, really. This is pathetic, but its also important to realise really sharing heavy duty facts, newish systems and supporting ideas, S/W, Data on and on it goes is generally more labor and time then most research line items.

What are those sad two steps ?

1) Incoherent Github with almost no worked examples. No real enabling stuffola, whatsoever. 

2) Fat database and web browser program. One is unusable due to no metadata, the other just falls apart after a couple months.

Did I mention a snazzy name for whatever it isn't ?

Oh, that's 3 things, sorry.

Can this be improved ? Well, yes but its a field of low expectations here. I mean, downloading a massive TAR or ZIP file and poking at it for 1/2 hour, is very close to a worthless, but not entirely,. "Something in here might do something !", is about all the end user gets. Watching the alleged support s/w fall apart is pretty sad, too. 

 Low expectations ! That's the firster activation code here ? Maybe....

Face it entirely too: George Church says only a company to try each thing has the pull to matter.  So then the science urge is turned into greasy unfulfilled promises and the counting of unhatched chickens for the bean counters.

"Did you boys get paid anything, by anybody, this week ?" is the sudden, in your face every day question, not whether it really works at all; ( phooey on that noise ).


Regs
Daniel B. Kolis; 17Aug2024



 

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Posted by Science

Re: [DIYbio] Streaming platform for science

7:18 AM |

Getting a patent is sometimes moderately challenging. I have two ( both pretty basic to the field... both long expired ).

https://patents.google.com/patent/EP0848391A1/en


Ahh. Universities and some companies, etc maybe more non-profits ( if that really exists, in reality )... Get patents to show off, not get paid.

 I think the explanation is 'papers' invariably spills the guts on ideas enough, if the patent isn't in the pipeline, its up for grabs entirely.

That is: Only people not in the inventor's hot seat think you get this thing granted / prosecuted successfully and there is some bag of gold on the table; --for the LIKES of YOU !

It takes surreal amounts of money to protect a patent if you have no initial paying customers. It takes years, and frequently the process of deciding is by people that don't know anything: ZERO. So it's a standard: "Your job as a lawyer is to lie, lie and if that doesn work, combine lies and begging, and evil stories". 

So, hmmm. Certainly many professionals intentionally hide the best part, quit, wait awhile and then try to make a company and not get in trouble. It certainly works enough of time to consider...

But, its not either easy, or reliable.

PROBABLY the very best way to monetize a patent is a fist cheap cheap secret $$ value license, followed by infinite aggression and/or deal making. "Abandonment, Priority, Interference" there are lots of ways a patent can be annulled or superseded even without considering whether it works, too.

If intellectual property generally interferes with life science expositions, its usually more greed and middle manager fantasy then planning. Easier to hide the best part intentionally undone, move, wait and pretend it is an independant development.

Note Stanford and MIT are constantly 'in trouble' with court actions that go on and on. Its no easy way to proceed.

But I mean, how else do you get $300K a year for each jar of pills to reverse a disability ( like Cystic Fibrosis ) that you did on a government's tab without considerable sneaky business ?

Telling the truth will get you nowhere fast. For instance, no legal people will want to deal with you whatsoever with an attitude like that.






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Posted by Science

Re: [DIYbio] Streaming platform for science

6:18 AM |

Thanks, Dan.

Dakota, I see what you're saying, but my PI specifically encouraged this. He has no plans to patent, and our field is more about working together than it is stealing ideas. Maybe we're just an exception though!

On Sat, Aug 17, 2024 at 12:39 PM Dakota Hamill <dkotes@gmail.com> wrote:
Always thought streaming science would be cool.  Then reality sets in.  That would probably kill any chance to patent or publish something.  Then your PI doesn't get a grant, then the University sues you, then you get fired.  

I'm being pessimistic but based on things I've seen and experienced, it's probably not far off.  

Someone's paying you to do that research presumably if you're at a University, and you're giving the results away for free and disclosing it to the public.  

I'm not saying that's the way it should be, but seems how it is. 

Jove is cool but paywalled.  

There used to be another more open video protocol website I forget the name of.  I thought it was like petri.com or experiment.com or labrat or bench something.  

On Sat, Aug 17, 2024, 11:47 AM Dan Kolis <dankolis@gmail.com> wrote:
Making real life science new knowledge shareable is really difficult. The amusing two steps done currently, are just morning kisses of blowing in the mirror of self adoration, really. This is pathetic, but its also important to realise really sharing heavy duty facts, newish systems and supporting ideas, S/W, Data on and on it goes is generally more labor and time then most research line items.

What are those sad two steps ?

1) Incoherent Github with almost no worked examples. No real enabling stuffola, whatsoever. 

2) Fat database and web browser program. One is unusable due to no metadata, the other just falls apart after a couple months.

Did I mention a snazzy name for whatever it isn't ?

Oh, that's 3 things, sorry.

Can this be improved ? Well, yes but its a field of low expectations here. I mean, downloading a massive TAR or ZIP file and poking at it for 1/2 hour, is very close to a worthless, but not entirely,. "Something in here might do something !", is about all the end user gets. Watching the alleged support s/w fall apart is pretty sad, too. 

 Low expectations ! That's the firster activation code here ? Maybe....

Face it entirely too: George Church says only a company to try each thing has the pull to matter.  So then the science urge is turned into greasy unfulfilled promises and the counting of unhatched chickens for the bean counters.

"Did you boys get paid anything, by anybody, this week ?" is the sudden, in your face every day question, not whether it really works at all; ( phooey on that noise ).


Regs
Daniel B. Kolis; 17Aug2024



 

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Posted by Science

Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

4:38 PM |

Is there a risk of an immune response?

On 8/18/2024 1:02 PM, jadams grg.org wrote:

It's all good Daniel.  I too am pretty tired of all the spam. 

 

In the meeting I showed a number of clinical studies, how it is used as a therapy for various medical conditions, and other reasons behind it. 

 

This is a clinical study to find out how well (or whether) it works.

3 arms

Therapeutic Plasma Replacement (TPR) – Replace plasma in seniors with thoroughly screened plasma from donors in their early 20s

Therapeutic Plasma Infusion (TPI) – Infuse seniors with thoroughly screened plasma from donors in their early 20s

– and –

Therapeutic Plasma Exchange (TPE) – Exchange plasma with saline and albumin

 

There will be different amounts of plasma and variations to find out what works best for a particular study subject.

 

What started me on this was that the TPE I had gave the best objectively measured and subjective results of any therapy I have ever tried.  Including umbilical cord plasma.  My expectation is that TPR will be even better.

 

For measurements and details, in the following link, scroll to

Fri Sept 23 (2022/09/23) – Therapeutic plasma exchange (TPE)

https://www.aginginterventionfoundation.org/JohnnyAdamsRecentRecords.pdf

 

There's too much to cover here, but there will be another presentation and I'll be recording it so you might want to tune in.

 

If OK I'll post the announcement here.

 

Cheers,

Johnny

 

From: diybio@googlegroups.com <diybio@googlegroups.com> On Behalf Of Daniel C.
Sent: Sunday, August 18, 2024 3:24 PM
To: diybio@googlegroups.com
Subject: Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

 

Ah, well, in that case I apologize.  I figured this was some sort of sales pitch in disguise.

 

I don't know much about therapeutic plasma replacement, but it doesn't really seem like it would do much.  I admit I'm biased because I heard it's popular in Silicon Valley, and I just assume that anything they do is a waste of money.  What evidence do you have that it has real effects?

 

On Sun, Aug 18, 2024 at 5:28 PM jadams grg.org <jadams@grg.org> wrote:

It is definitely not a for-profit enterprise.  The Carl I. Bourhenne Medical Research Foundation dba Aging Intervention Foundation is a 501 (c)(3) and the Gerontology Research Group is a volunteer organization.

 

My intention with posting the announcement was to provide valuable information.

 

I'm a DIY guy, not so much an institutional researcher. 

Here are some of the things I've done, most of it DIY

https://www.aginginterventionfoundation.org/JohnnyAdamsRecentRecords.pdf

 

You asked about rapamycin - I take rap. It's one of the therapies available now to help get a few more good years.  Useful along with nutrition/fasting, exercise, sleep, probiotic foods, some supplements, other prescriptions like metformin, dasatinib, etc.  Along with things like pure water, dental care, reducing risks, and a few others.

 

I'm on a roll here and it's Sunday and no pressing engagements,

so I'll go all in and write some things I was hesitant to over a concern of being considered not within the guidelines or spam.

 

I'm in this to create solutions for open ended life – healthy of course, and making the world a better place. 

At age 74 I'm determined to develop therapies to be young again – age 26.

 

The top 3 in the subject of my talk:

Therapeutic plasma replacement.  I'm leading this one.

 

That's a bridge to developing

Advanced Exosomes and Other Plasma-Derived Therapies for greater system-wide age reversal. 

 

Together the two are a bridge to

Yamanaka / OSK Gene Therapy to reset the epigenome toward youth / cellular reprogramming.   I am a part of the team that's developing these.

 

Let me know if you believe others are more important.  I would easily jump to something better.

 

We'll stay tuned to developments in others like mitochondrial, senolytic, microbiome, gene therapy etc, and help with their development.

 

In my talk I make it clear I'm not in it for the money – I want the therapies, for myself and our community, and to make the world an even better place.

 

Cheers,

Johnny

https://www.aginginterventionfoundation.org/JohnnyAdams.pdf

 

From: diybio@googlegroups.com <diybio@googlegroups.com> On Behalf Of Daniel C.
Sent: Sunday, August 18, 2024 10:05 AM
To: diybio@googlegroups.com
Subject: Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

 

I don't know, that's why I asked. I would assume that promotion of one's own for-profit enterprise (even though it's one I'm definitely interested in) is frowned upon.

 

Then again it's not like you're interrupting a thriving, active community ;-)

 

Tell me, what are your thoughts on rapamycin?

 

On Sun, Aug 18, 2024, 4:06 PM jadams grg.org <jadams@grg.org> wrote:

What are the posting guidelines?

 

 

 

From: diybio@googlegroups.com <diybio@googlegroups.com> On Behalf Of Daniel C.
Sent: Sunday, August 18, 2024 2:09 AM
To: diybio@googlegroups.com
Subject: Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

 

So, does this count as spam?

 

On Sat, Aug 17, 2024, 6:49 PM jadams grg.org <jadams@grg.org> wrote:

This relates to DIY.

 

Hoping you can join our online meeting.

Regrets for the late notice, if this announcement is welcome I'll let you know about the next one.

 

Today Saturday  Aug 17

10:00 am Pacific,   1:00 Eastern

 

I'll show slides and we'll talk about

 

Why I'm staking my Life on

the Three MOST Important Age Reversal Therapies

to be Young Again

 

Zoom Meeting

https://us02web.zoom.us/j/89815838780?pwd=Hrh6MzjayJeDIbeu1h0s927Me9yORS.1

 

Meeting ID: 898 1583 8780

Passcode: 307133

 

Johnny

 

 

John M "Johnny" Adams

CEO / Exec. Director  Bourhenne Medical Research Foundation dba Aging Intervention Foundation

Executive Director Gerontology Research Group

160 W Camino Real   No 204   Boca Raton, FL 33432   1-954-493-3414

3857 Birch St  No 182 Newport Beach, CA 92660    1-949-922-9786

JAdams@AgingIntervention.org

https://www.AgingInterventionFoundation.org/JohnnyAdams.pdf

https://www.AgingIntervention.org

 

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RE: [DIYbio] Relates to DIY - Hoping you can join our online meeting

1:02 PM |

It's all good Daniel.  I too am pretty tired of all the spam. 

 

In the meeting I showed a number of clinical studies, how it is used as a therapy for various medical conditions, and other reasons behind it. 

 

This is a clinical study to find out how well (or whether) it works.

3 arms

Therapeutic Plasma Replacement (TPR) – Replace plasma in seniors with thoroughly screened plasma from donors in their early 20s

Therapeutic Plasma Infusion (TPI) – Infuse seniors with thoroughly screened plasma from donors in their early 20s

– and –

Therapeutic Plasma Exchange (TPE) – Exchange plasma with saline and albumin

 

There will be different amounts of plasma and variations to find out what works best for a particular study subject.

 

What started me on this was that the TPE I had gave the best objectively measured and subjective results of any therapy I have ever tried.  Including umbilical cord plasma.  My expectation is that TPR will be even better.

 

For measurements and details, in the following link, scroll to

Fri Sept 23 (2022/09/23) – Therapeutic plasma exchange (TPE)

https://www.aginginterventionfoundation.org/JohnnyAdamsRecentRecords.pdf

 

There's too much to cover here, but there will be another presentation and I'll be recording it so you might want to tune in.

 

If OK I'll post the announcement here.

 

Cheers,

Johnny

 

From: diybio@googlegroups.com <diybio@googlegroups.com> On Behalf Of Daniel C.
Sent: Sunday, August 18, 2024 3:24 PM
To: diybio@googlegroups.com
Subject: Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

 

Ah, well, in that case I apologize.  I figured this was some sort of sales pitch in disguise.

 

I don't know much about therapeutic plasma replacement, but it doesn't really seem like it would do much.  I admit I'm biased because I heard it's popular in Silicon Valley, and I just assume that anything they do is a waste of money.  What evidence do you have that it has real effects?

 

On Sun, Aug 18, 2024 at 5:28 PM jadams grg.org <jadams@grg.org> wrote:

It is definitely not a for-profit enterprise.  The Carl I. Bourhenne Medical Research Foundation dba Aging Intervention Foundation is a 501 (c)(3) and the Gerontology Research Group is a volunteer organization.

 

My intention with posting the announcement was to provide valuable information.

 

I'm a DIY guy, not so much an institutional researcher. 

Here are some of the things I've done, most of it DIY

https://www.aginginterventionfoundation.org/JohnnyAdamsRecentRecords.pdf

 

You asked about rapamycin - I take rap. It's one of the therapies available now to help get a few more good years.  Useful along with nutrition/fasting, exercise, sleep, probiotic foods, some supplements, other prescriptions like metformin, dasatinib, etc.  Along with things like pure water, dental care, reducing risks, and a few others.

 

I'm on a roll here and it's Sunday and no pressing engagements,

so I'll go all in and write some things I was hesitant to over a concern of being considered not within the guidelines or spam.

 

I'm in this to create solutions for open ended life – healthy of course, and making the world a better place. 

At age 74 I'm determined to develop therapies to be young again – age 26.

 

The top 3 in the subject of my talk:

Therapeutic plasma replacement.  I'm leading this one.

 

That's a bridge to developing

Advanced Exosomes and Other Plasma-Derived Therapies for greater system-wide age reversal. 

 

Together the two are a bridge to

Yamanaka / OSK Gene Therapy to reset the epigenome toward youth / cellular reprogramming.   I am a part of the team that's developing these.

 

Let me know if you believe others are more important.  I would easily jump to something better.

 

We'll stay tuned to developments in others like mitochondrial, senolytic, microbiome, gene therapy etc, and help with their development.

 

In my talk I make it clear I'm not in it for the money – I want the therapies, for myself and our community, and to make the world an even better place.

 

Cheers,

Johnny

https://www.aginginterventionfoundation.org/JohnnyAdams.pdf

 

From: diybio@googlegroups.com <diybio@googlegroups.com> On Behalf Of Daniel C.
Sent: Sunday, August 18, 2024 10:05 AM
To: diybio@googlegroups.com
Subject: Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

 

I don't know, that's why I asked. I would assume that promotion of one's own for-profit enterprise (even though it's one I'm definitely interested in) is frowned upon.

 

Then again it's not like you're interrupting a thriving, active community ;-)

 

Tell me, what are your thoughts on rapamycin?

 

On Sun, Aug 18, 2024, 4:06 PM jadams grg.org <jadams@grg.org> wrote:

What are the posting guidelines?

 

 

 

From: diybio@googlegroups.com <diybio@googlegroups.com> On Behalf Of Daniel C.
Sent: Sunday, August 18, 2024 2:09 AM
To: diybio@googlegroups.com
Subject: Re: [DIYbio] Relates to DIY - Hoping you can join our online meeting

 

So, does this count as spam?

 

On Sat, Aug 17, 2024, 6:49 PM jadams grg.org <jadams@grg.org> wrote:

This relates to DIY.

 

Hoping you can join our online meeting.

Regrets for the late notice, if this announcement is welcome I'll let you know about the next one.

 

Today Saturday  Aug 17

10:00 am Pacific,   1:00 Eastern

 

I'll show slides and we'll talk about

 

Why I'm staking my Life on

the Three MOST Important Age Reversal Therapies

to be Young Again

 

Zoom Meeting

https://us02web.zoom.us/j/89815838780?pwd=Hrh6MzjayJeDIbeu1h0s927Me9yORS.1

 

Meeting ID: 898 1583 8780

Passcode: 307133

 

Johnny

 

 

John M "Johnny" Adams

CEO / Exec. Director  Bourhenne Medical Research Foundation dba Aging Intervention Foundation

Executive Director Gerontology Research Group

160 W Camino Real   No 204   Boca Raton, FL 33432   1-954-493-3414

3857 Birch St  No 182 Newport Beach, CA 92660    1-949-922-9786

JAdams@AgingIntervention.org

https://www.AgingInterventionFoundation.org/JohnnyAdams.pdf

https://www.AgingIntervention.org

 

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