" Assuming human-derived sequences hold no potential danger greater than what nature poses is a major problem, in my view. We are bypassing natural barriers that would likely prevent certain sequences from ever existing. "
Have you considered that this problem may only exist in your head? These barriers do not exist. Species are made up by humans. There's literally hundreds of papers about horizontal gene transfer and how often it happens in nature. Also, I'll have to look up how many billions of mutations you get in the yield of a 1 hectar field.
On Monday, June 3, 2019 at 12:06:05 AM UTC+2, Matt Endrizzi wrote:
-- Have you considered that this problem may only exist in your head? These barriers do not exist. Species are made up by humans. There's literally hundreds of papers about horizontal gene transfer and how often it happens in nature. Also, I'll have to look up how many billions of mutations you get in the yield of a 1 hectar field.
Labs work with plasmids and as long as they autoclave and bleach everything, nothing gets out. And for all scientific evidence we have, it should be fine even if we released it. What makes you think nature has a plan and can't horribly go wrong?
Also, considering how much effort we put into makeing this planet uninhabitable.... By burning coal, which releases both particulate matter and radioactive minerals (which cause mutations) and gas and oil, releasing huge ammounts of greenhouse gasses. End even besides that, cutting down the rainforest and making so many species extinct. Causing eutrophication and euxinia, and possibly triggering the ocean to tip and release hydrogen sulfide and cause a new mass extinction. Breeding atibioti-resistant bacteria and yeasts by using the same antibiotics and fungicides in agriculture that we use for medicine. These are the problems. Talking about rDNA and thinking it hasany effect - especially that most are following current guidelines - is ridiculous.
On Monday, June 3, 2019 at 12:06:05 AM UTC+2, Matt Endrizzi wrote:
I recognize there is a great deal of friction fighting against DNA. We also know some sequences have become very successful. Oligos and PCR are not on my radar. Processes that make novel sequences greater than 200 bp are.
While many probably think I'm overzealous in my dire predictions, I here you. I perhaps just don't have the same confidence as others seem to have in claiming to understand evolutionary processes. I think our understanding about evolution is still quite nascent. Assuming human-derived sequences hold no potential danger greater than what nature poses is a major problem, in my view. We are bypassing natural barriers that would likely prevent certain sequences from ever existing. With the advent of recombinant DNA technology, we have entered a whole new biohazard realm.
While this is an old letter from Ted Kennedy, it summarizes the agreement made by the scientific community to promise the public to contain recombinant DNA and not let it out into the environment.
https://profiles.nlm.nih.gov/ps/access/FFBBHV.pdf
While dialogue around risk has subsided from public awareness since the publishing of the NIH Guidelines, I am not aware that this containment promise has been withdrawn.
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