Not trying to end this discussion, but from my experience and knowledge from reading scientific literature and my studies, your concerns seem more like a gut feeling than a reasonable fear.
-- Sure: if someone farts, it coud trigger a hurricane somewhere, which then reflects sunlight which radiates onto a meteor and directs it towards Earth. Scientifically speaking you could probably think of a way how this could happen. Probability is very low.
Using pUC plasmid, adding a mouse gene expression cassette and saying this is gonna turn into a useful virus.... or it may mix with influenza and create a super-virus.... sounds pretty bonkers. Especially when you are not working with viral *biosafety level 2 or BSL3* and immmunoevasion proteins thereof. Which you aren't allowed anyways. And I bet an amateur would have a hard time figuring out which of these viral genes will actually integrate and work. Even experts can't, and most experiments just don't work. And what motivation would anyone have to do that.
So in my opinin that's just ignoring what happens in nature and disproportionally assessing risks. We have how many? 50 years experience with recombinant DNA?
Precautionary principle is important. Not stopping science because of gut feelings and natural fallacy is also important. You know, we need more efficient agriculture, or this planet won't stand another 40 years. It's vertebrate biosphere, I mean.
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