The Zhang paper actually examined several miRNAs (MIR156a, MIR168a and MIR166a) from several plant sources, both cooked and uncooked (including rice, potatoes, wheat and bok choy).
You're absolutely right, though, in that it warrants significant further exploration before any meaningful claims could be made about the impact of one veggie or another.
To me, though, this is absolutely fascinating. It might hold tremendous implications for synth bio and therapeutic RNAi.
On Saturday, September 24, 2011 11:56:43 AM UTC-4, Tom Randall wrote:
-- On Saturday, September 24, 2011 11:56:43 AM UTC-4, Tom Randall wrote:
On Sep 23, 12:55 pm, Patrick Yizhi Cai <caiyi...@gmail.com> wrote:
> This claim is biased and not fair. Are you going to resequence all the genomes done by BGI as well?
>
It is a fair statement. This finding applies to one miRNA (MIR168a) in
one species of plant, rice. It cannot be extrapolated to all or even
some other miRNA-mRNA interactions in mammals eating other vegetables
based on one study. Other such interactions would have to be tested
before this finding can be generalized. It should also be repeated by
other laboratories. Consider the following, a few years ago chronic
fatigue syndrome was linked to a virus (xenotropic murine leukemia
virus-related virus, or XMRV) by one lab which was a potentially major
breakthrough in understanding this disease. Others could not repeat
this finding and currently this relationship is in doubt. It may be
that there was some reagant contamination in that specific lab that
was causing this correlation. Anyhow, the point is that any result
like this that might have value in understanding a disease or may have
some therapeutic effect should be repeatable. If it can be, then great.
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