Re: Math and bio?

This lab is doing some really cool whole-cell modelling:
http://covertlab.stanford.edu/subpages/research.php
they're quite a long way from neuro, but they do model transcription
(albeit in a really small genome). Mine their bibliographies!
On Dec 22, 9:20 am, Jonathan Nesser <jonathan.nes...@gmail.com> wrote:
> I've been getting into mathematical models lately, and have noticed
> that many of these models don't really take into account the signaling
> complexities of biology. To this end I was wondering if anyone could
> point me in the direction of a general equation, etc. that models
> either the process of selecting a gene to be transcribed in a cell
> (all of the different transcription affinity and negating factors), or
> of quantifying the amount of mobilization of an enzyme which is
> activated through a complex enzyme cascade. A name of an equation or
> modeling style would be enough to get me started, I haven't been able
> to find much of anything beyond the idea of the stochastic general
> equation and markov, non-markov type equations. To put a context to
> this broad question, I'm interested in the ligand gated g protein
> receptor cascades in neurons, and the control of receptor populations/
> synapse modulation (synaptic placticity) at a genetic (or at any
> other) level. Having looked over a goodly amount of articles it seems
> to me like this has been mainly studied at a qualitative level, much
> less so at a specific quantitative level. Sorry to pollute the board
> with my neuroscience again :P, but I think this would be interesting
> to the slightly higher level genetics researchers here as well. :)
> Thanks for any information in advance, and I apologize for my
> ignorance if this is a commonly understood topic, I don't really have
> access to a professor of, well, anything. :)
>
> Jonathan Nesser
> diybioandneurosci.blogspot.com

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