Radio opaque biomolecule?

Recently i had some ideas about radioimaging gene expression. There
are many ways to study gene expression like using flourescent protien
tags. but all those requires sacrificing the animal for taking tissue
sections for immuno histochemistry. so i was searching some concepts
for visualizing gene expression within specific tissues inside the
body by some imaging techniques.Incidentally i came across bio
activated contrast agents.You can see that in this link <link>http://
www.nibib.nih.gov/HealthEdu/eAdvances/23Oct06<link>. But instead of
using contrast agent i'm just curious to know is there anything like
any protien or any biomolecule which is naturally radio opaque whose
gene can be sandwiched with the promoter of the gene of interest and
so we can image the the tissue and study the gene expression without
killing the animal.....

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