Recently I've been really interested in the idea of designing 'good
bacteria' to do even more good for the gut. I've conceived of a way to
design Bifidobacteria (with 2 genes --> 2 enzymes) to destroy fat
before it's absorbed into the body or excreted in feces. This would be
a really cool designer probiotics that would benefit so many people,
particularly those on high fat diets (obesity). Taking Bifidobacteria
longum as a supplement has been shown to resist diet-induced obesity
and mitigate metabolic syndrome in rodents but of course the effects
are marginal. My goal is to shift metabolism towards fat degradation
in these designer probiotics to deliver appreciable benefits. It'd be
nice to have someone to bounce ideas with. Let me know if your
interested so I can send you some good literature on this.
I'll be doing much of the work between City College and GenSpace in
Brooklyn. Anyone in the area?
Bam!,
Rahim
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