Re: [DIYbio] Re: Designer Probiotics. Anyone interested in this?

Knocking out sucrase will leave lots of undigested sucrose in your GI tract and give you a nice osmotic diaorrhea. Not going to do much for the sales of Coke (unles it's Diet). You will lose weight though :-)

Zeb

To address sugar, try knocking down sucrase expression, perhaps using modified plant miRNAs, and give yourself an upper tract probiotic that produces levansucrase. Undigested sucrose is probably poorly digested, and the conversion of sucrose to levan (a prebiotic/gut conditioner) turns a poison into a mild beneficial compound.

Alternatively, omit the levansucrase part: cramping and diarrhea from undigested sucrose will teach you to stop drinking coke in the first place.

romie <ryrolitt@gmail.com> wrote:

>I'm really interested in the idea of modified got bacteria. I don't
>really care about the obesity issue compared to overall health but I
>think the problems of integrating something new into such a complex
>environment is a shared problem. I'm not in your area but can pursue
>this idea at LA biohackers.
>
>Romie
>
>
>On Feb 28, 9:11 am, naiverahim <rahim.ba...@gmail.com> wrote:
>> Recently I've been really interested in the idea of designing 'good
>> bacteria' to do even more good for the gut. I've conceived of a way
>to
>> design Bifidobacteria (with 2 genes --> 2 enzymes) to destroy fat
>> before it's absorbed into the body or excreted in feces. This would
>be
>> a really cool designer probiotics that would benefit so many people,
>> particularly those on high fat diets (obesity). Taking Bifidobacteria
>> longum as a supplement has been shown to resist diet-induced obesity
>> and mitigate metabolic syndrome in rodents but of course the effects
>> are marginal. My goal is to shift metabolism towards fat degradation
>> in these designer probiotics to deliver appreciable benefits. It'd be
>> nice to have someone to bounce ideas with. Let me know if your
>> interested so I can send you some good literature on this.
>>
>> I'll be doing much of the work between City College and GenSpace in
>> Brooklyn. Anyone in the area?
>>
>> Bam!,
>> Rahim
>
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