Regarding myostatin knockout animals, the protein has a wide range of
functions outside of muscle; in fact, I'm surprised they survive as
well as they do, since very few gene knockouts are able to be shrugged
off with such relative ease. If one considers the scenario of
myostatin inhibition specifically in the muscle, and after the onset
of adulthood, many of the side-effects could potentially be avoided.
Just like with anabolic steroids, the off-target effects are what
really limit you.
I am in agreement with your skepticism on its use in treating muscular
dystrophy; it's akin to filling up the tank on a burning car. Sadly,
MD is the only excuse by which researchers can get funding, since
enhancement isn't really the focus of the clinical trial system, at
least these days. I'll keep you updated if it works.
On Mar 2, 10:23 am, mad_casual <ademloo...@gmail.com> wrote:
> I wasn't concerned about wear and tear. Let me say it this way, I have
> some experience gaining muscle without exercising; or to a level
> higher than what exercising was inducing. I'm sure you're aware that,
> myostatin knockout and mutant infants die more often than their wild-
> type counterparts. I'm sure you know that anti-sense myostatin alone
> makes muscular dystrophy worse because it enhances contractile
> elements without enhancing connective and structural elements. (It is
> touted/suspected/makes sense that)Humans hypertrophied in excess of
> what they can do exercising suffer ill effects along the same pattern.
> Hell, at 6'2" you or someone you know at the same height probably had
> tendinitis/tendinosis simply from growing bigger naturally.
>
> Not telling you not to try it, it sounds fun and it sounds like now
> (or soon) is the time to try it; I'm just saying my kids are impressed
> with what I can lift, I'm thankful that I can lift them (most of the
> time). You sound like you know the harm you could be doing to yourself
> and I couldn't stop you if I wanted to; it was the proliferation on
> the internet (with associated optimism) that gave me reservations. Am
> I a muscle/bio geek or just way over-parenting? Either way, I look
> forward to results or publications as they become available.
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