Supplementary data from publication which includes the SNPs (see table S1) below.
Who wants to make a test kit?
http://www.sciencemag.org/content/suppl/2010/06/30/science.1190532.DC1/Sebastiani_SOM.pdf
Video, http://www.youtube.com/watch?v=uPE7S27O5ok
Publication abstract (note there is a retraction to this paper which qualifies and lessens the 77% accuracy result, due to bugs in their protocol & equipment):
"""ABSTRACT
Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls. Using these data, we built a genetic model that includes 150 single-nucleotide polymorphisms (SNPs) and found that it could predict EL with 77% accuracy in an independent set of centenarians and controls. Further in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characterized by different combinations of SNP genotypes—or genetic signatures—of varying predictive value. The different signatures, which attest to the genetic complexity of EL, correlated with differences in the prevalence and age of onset of age-associated diseases (e.g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging."""
References:
* Discussion of retraction, http://uncertaintist.files.wordpress.com/2011/08/science-retraction-2011.pdf
* Supporting Online Material for Genetic Signatures of Exceptional Longevity in Humans, http://www.sciencemag.org/content/suppl/2010/06/30/science.1190532.DC1/Sebastiani_SOM.pdf
* Genetic Signatures of Exceptional Longevity in Humans, http://www.bumc.bu.edu/medicine/files/2010/07/longevity-genes.pdf DOI: 10.1126/science.1190532
* Youtube interview with researchers, http://www.youtube.com/watch?v=uPE7S27O5ok
## Jonathan Cline
## jcline@ieee.org
## Mobile: +1-805-617-0223
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