Re: [DIYbio] The Drugs That May Never Be Used -- AKA acute radiation syndrome (ARS) drugs

But this isn't a drug candidate for "radiation exposure", in which case
you're more worried about cancer. This is a treatment for "acute
radiation sickness", where a significant fraction of your body,
especially your stem cells, commit apotosis all at once, killing you
painfully.

Generally, you want mutant cells to apoptose, yes. But perhaps not all
at once! :)

On 30/08/12 22:35, Nathan McCorkle wrote:
> http://cen.acs.org/articles/90/i26/Drugs-Never-Used.html
>
> "
> Cleveland BioLabs has been trying to move its lead candidate, CBLB502,
> along this development path. The drug is an injectable recombinant
> derivative of a bacterial protein flagellin that activates signaling
> pathways and suppresses apoptotic cell death in hematopoietic and GI
> cells. The firm also is exploring CBLB502 as a radioprotectant in
> medical procedures. It has completed animal efficacy and human safety
> studies, and it has regulatory-compliant manufacturing.
> "
>
> seems like you'd want radiation-damaged cells to apoptose, rather than
> continue and possibly mutate into a cancer. CONSPIRACY THEORY: if this
> actually got approved, people would think it was great, but it could
> in reality just keep them coming back.
>
> This just seems like shrewd marketing by pharma... to keep themselves
> in business, the old 'it looks good in short-term, but keeps patients
> coming back'
>
>
>

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