[DIYbio] Fwd: Intein control in a targeted cancer therapy

Hello,

I'm not sure if your group is the right place for me to look for help, but I thought it worth a shot.

I am self-taught in the biosciences… Neuroscience, Genetics, Immunology, and Targeted Cancer Therapies.  After watching a presentation on Chimeric Antigen Receptors on the NIH site, I had an idea on another approach that would remove the limitations inherent in the technique presented (though it was a fantastic step forward, and very successful).  My approach is based on a constitutively active Caspase 3 mutant controlled by a molecular switch.

Long story short… I just wrote up a few paragraphs on my idea and sent it off to a few people in the field.  One of them (a senior scientist from Pfizer) got back to me a few months later and said I may be on to something and that I needed to write a paper.  I did  that and then wrote an article on that paper with him and that was published in a small time online journal last year.  Since then my paper and the article have been download several hundred times.

I didn't provide the links or an attachment as my first attempt to send this email was blocked by spam filters.. I will provide that information if you have interest.  In the interim, you can search for "intracellular Caspase modulating Chimeric Antigen Receptor".

Thank you very much for your time…

Take care,

Scott