Hello Cathal,
Actually, we are trying to block IRES(Internal Ribosomal Entry Site), so that it silences the viral infection.
Also,we are looking for DNA or peptide based aptamers as RNA aptamers are difficult to handle because of their stability and structure.
Yes it's the reverse complementary to IRES sequence,but designing an aptamer for particular sequence is different and it is done using SELEX.
Any library or software which are specifically for aptamers helps in finding in our motive.
Thanks
Regards:
aayush aggarwal
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