Re: [DIYbio] Oxalobacter formigenes probiotic suppliers? was: (Re)Becoming Human: what happened the day I replaced 99% of the genes in my body

On 09/30/2014 11:49 PM, Nathan McCorkle wrote:
> The article mentions Oxalobacter formigenes being present in significant
> percentage in the Hadza, and that this is something that western
> microbiomes pretty much lack.
>
> I tried googling oxalobacter probiotic, but didn't get very far. Is this
> something that doesn't exist? If it does, can someone post a link here?
> I've got a friend with kidney stones who has been living with them due
> to lack of western healthcare insurance.
>

well, the short answer is that it does not seem to exist (yet), but some
people are already looking into making capsules with Oxalobacter
formigenes (and to market them as a drug).


More details:

From a short search there seems to be a Swedish company which aims to
market capsules[0] with Oxalobacter formigenes as a treatment for
Primary Hyperoxaluria. It also aims to market an orally delivered drug
composed of recombinant oxalate decarboxylase to prevent formation of
calcium-oxalate kidney stones [0]. Apparently, there is a clinical
trial[1] going-on and they are recruiting participants in France,
Germany and the UK.


It might be of interest that at the moment there are available
supplements with other bacteria, which may affect oxalate levels
(according to a limited number of studies). (You might have already read
about them, I have not delved into this subject in the past). In the
following paper (2005), entitled "Use of a probiotic to decrease enteric
hyperoxaluria", they've used Oxadrop®[3] which is similar to VSL#3 [4 & 5].

Another study[6] performed in 2010, indicated a decrease in oxalate
levels with VSL#3, albeit to a small number of healthy people.


However, looking into the subject of present and future treatments for
kidney stones, I found this review[7] from 2013, which says the following:

"The role of oxalate-degrading bacteria, such as O. formigenes, in CaOx
stone formation is a subject of current research. A pilot study showed
O. formignenes reduced plasma oxalate levels and urinary oxalate
excretion in the majority of PH patients [105], but the results could
not be unequivocally confirmed in a recent multicenter trial. There are
also inconsistent results with regard to the use of lactic acid bacteria
(probiotics) to reduce urinary oxalate excretion [106]. Treatment that
involves the upregulation of intestinal luminal oxalate secretion by
increasing anion transporter activity (Slc26a6), or use of oxalate
binders is another approach [107]."


So, maybe your friend could try VSL#3 (if he has not tried it already),
keeping in mind that it might not have an affect. I would also suggest
having a look at the review, it has some interesting info.


have a nice afternoon & the best of luck to your friend :)


elusive


[0] http://www.oxthera.com/products/
[1] https://clinicaltrials.gov/show/NCT02012985
[2] http://www.nature.com/ki/journal/v68/n3/full/4496205a.html
[3] Oxadrop®:
Lactobacillus acidophilus, L. brevis, Streptococcus thermophilus, and
Bifidobacterium infantis in a 1:1:4:4 ratio
[4] VSL#3:
3 of the above [see note 3] 4 bacterial species with the exception of L.
brevis, as well as 3 other species of Lactobacillus, and 2 other species
of bifidobacteria.
[5] http://www.vsl3.com/
[6] https://www.ncbi.nlm.nih.gov/pubmed/20224931
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772648/

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