[DIYbio] Do cells of the same type in different species act differently with the same DNA?

That is if you took something like a liver cell of a giraffe and a lizard and switched the DNA or an embryonic stem cell of a walrus and a frog and switched the DNA would the cell operate under the new set of DNA or would there be variations either due to genes that had already been expressed in building the cell or intracellular machinery that is species-specific?

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