Re: [DIYbio] saccharomyces cerevisiae potentialities

Wow, sounds like you just landed a job as microbiology-Willy-Wonka!
Congratulations, can't wait to see what you do with it. :)

As far as "awesome stuff to do with yeast", there's plenty of
neutriceutical hacks you could replicate, like resveratrol beer. There's
also plenty of utilitarian stuff you could try, ways of producing
difficult things, or under difficult conditions.

I was told by someone who ought to know, that a major biofab out there
uses a custom, directed-evolution-bred, strain of yeast that grows as
low as pH 3.X, a startlingly low pH for a yeast! The idea was that you
can avoid contamination by growing things at such low pH, I don't know
how much use it sees however. It is, sadly, proprietary; I wonder how
hard that would be to replicate? Whether by DirEvo or Synbio?

While we're on the subject of "wyrd yeest", what about psychrophilic
yeast? Or thermophilic?

There's already a talented team working on cannabinoid yeast, how about
circumin? Or vitamin B12? Or berberine?



On 26/12/14 17:29, Nick M. wrote:
>
> All,
>
> Hope everyone had lovely and peaceful holidays.
>
> I've been lurking the group for ~16 months now. So far I've done a GFP
> plant, selective breeding on plants, selective breeding on brewer's
> yeast, and a few other random projects. I want to thank you all for the
> invaluable depth of knowledge that is available here.
>
> I am a brewer by profession and have recently taken over a brewery with
> considerable corporate backing, corporate has told me 'Do what you want,
> don't break anything, and most importantly make great beer.'
>
> I take this to me I can build my own synbio lab, I am confident that is
> within my AOR.
>
> I was hoping to receive some input from you all on interesting
> directions to go with S. cerevisiae.
>
> I have seen the iGEM projects on beer, caffeine, limonene(particularly
> interesting to me), and kumamolisin, and all of those are things I would
> like to work towards.
>
> Any ideas on what I can do in the interim whilst trial running my lab
> and knowledge base? Looking for projects that would be valuable to me in
> either an academic or practical regard that would build a good framework
> of experience to operate on in a professional standard. I also feel
> indebted to the community and must offer my position to the benefit to
> the diybio community once it becomes a position of value.
>
> Cheers,
> Nick
>
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