It would seem to me that the main problem in transferring liquid from one block to another is basically the problem of pushing on a rope. The liquid will try to go everywhere except where you want it.
The alternative that suggests itself is to pull the liquid from one block to another using a relative vacuum. Now the liquid wants to go only where you want it to go.
On Fri, Feb 27, 2015 at 3:09 PM, <scocioba@gmail.com> wrote:
I'm my attempts at making modular units, transfer of discrete liquid packets or even continual flow is tough when you need to move from one chip to another. Alignment, pressure tolerance, hydrophobicity, etc all play a role in getting things up and through.
I tried using tubes as connections and found that slurping and sputtering happens. Aligning chips is a whole other can of grief if you want to make continual modular chips. The Lego based chips seen here:
http://www.redorbit.com/news/science/1113239467/lego-inspired-microfluidics-092214/
Need a very high degree of hole punch, die cutting and overall "machining" to mate well. ShrinkChips are variable during shrink and can lead to small defects. Connecting "millifluidic" chips involving >500um features but at super low volume pressure is an issue. If you don't have a coronal treater or rig a microwave to oxidize the pdms, pressure becomes even more of an issue. I've been spattered with food coloring trying to get a simple 100um T junction working...soooo....yeah. I'm very very interested in alternatives but if the kit is SU-8 at home, I'm out. Its so expensive and the overhead to do it well may be a bit much for the first time lab builder. Just my 2¢...
Sebastian S. Cocioba
CEO & Founder
New York Botanics, LLC
Plant Biotech R&D
From: GO
Sent: 2/27/2015 1:22 PM
To: diybio@googlegroups.com
Subject: [DIYbio] Re: At home fabrication of micron scale microfluidicsCan you make lego kind of system? For example, make separate components: channels, valves, chambers with different functions and then sell those? The purpose is that anyone can then assemble a desired system easily since PDMS can be bonded. Otherwise your resolution is my problem and also hydrophobicity of pdms.--Legos can be easier to sell and manufacture too. I would buy some components for ~$100 but for <20 microns resolution. The purpose would be to embed side electrodes for detection and play with that.
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