[DIYbio] Re: notahelix.net

I forgot to mention that we also think of these things from a
simulation standpoint... but computers still computer quite slowly
when you have so many molecules and so many interactions to account
for.

On Fri, Oct 2, 2015 at 12:05 AM, Nathan McCorkle <nmz787@gmail.com> wrote:
> There are definitely people at Universities teaching that DNA isn't
> always in a canonical form. Here are some recent studies that are
> getting close and closer to looking at things in their natural state,
> we're on our way to approach Heisenberg's uncertainty principle. There
> are plenty of people who want to know what is really going on.
>
> How I searched:
> (used the terms 'cryo em DNA nucleus in-vivo tomography' and then
> chose since 2011, then since 2015, added helical, removed in-vivo,
> removed nucleus... etc...)
> https://scholar.google.com/scholar?q=cryo+em+DNA+nucleus+in-vivo+tomography&btnG=&hl=en&as_sdt=0%2C38&as_ylo=2011&as_vis=1
>
>
>
> Analysis of chromatin fibers in Hela cells with electron tomography
> http://link.springer.com/article/10.1007/s41048-015-0009-9/fulltext.html
>
> Analysis of cryo-electron microscopy images does not support the
> existence of 30-nm chromatin fibers in mitotic chromosomes in situ
> http://www.pnas.org/content/105/50/19732.full
> (that one is from 2008)
>
> Chromatin structure: does the 30-nm fibre exist in vivo? Curr Opin Cell Biol
> http://www.researchgate.net/profile/Kazuhiro_Maeshima/publication/42609370_Chromatin_structure_does_the_30-nm_fibre_exist_in_vivo/links/5437ccb50cf2d5fa292b695d.pdf
>
> Chromatin as dynamic 10-nm fibers
> http://www.researchgate.net/publication/261743937_Chromatin_as_dynamic_10-nm_fibers
>
>
>
>
>
> --
> -Nathan



--
-Nathan

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