Aside from the safety of the process, I wouldn't want to overexpress growth hormone. That's lifespan-reducing stuff in animals, and there's at least circumstantial evidence for it applying in humans (correlational research showing that people who sleep less live longer, despite all the stress-related drawbacks).
On Thursday, January 12, 2017 at 10:53:23 PM UTC+1, Mega [Andreas Stuermer] wrote:
-- On Thursday, January 12, 2017 at 10:53:23 PM UTC+1, Mega [Andreas Stuermer] wrote:
Hey guys. I came across this story
https://www.technologyreview.com/s/603217/one-mans-quest- to-hack-his-own-genes/?utm_ campaign=internal&utm_medium= homepage&utm_source=cover- story
It seems that somebody injected himself with plasmid DNA and electroporated it then. His goal was to express human growth hormone, to increase his muscle mass (body size will not affected after age 25 obviously).
Besides any ethical concerns, I wonder if this is *safe*. For what I know, the treatment may cause anti-dsDNA antibodies and anti-nuclear antibodies, no? the worst outcome would then be autoimmune disease such as lupus?
On the other hand some studies suggest that injecting DNA doesn't necessarily produce these antibodies, this happens mainly if proteins are bound to the therapeutic DNA.
But the DNA will be amplified by bacteria so it will be methylated (e.g. Dam methylation) - wont that cause immune response and/or silencing?
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