Imagine there were no amplification errors and no radiation mutations. Then the world would still be settled with the first viable organism ;)
-- With E coli you are definitely right. In theory there could be a bacterium that can only grow hen Amp is present, if all the other metabolic enzymes have mutated and only ampicillin could be used as energy source. Some bacteria can't be cultivated in a dish because they live in communities in nature.
Stay curious ;)
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