[DIYbio] Do proteins fold differently when folded by different cells?

Not necessarily different cells within a single organism, but say you were to splice a really large protein from a Human into a bacteria or the other way around (or any animal or plant or fungus, etc) - when the cell goes to synthesize that protein would it be likely to fold differently?  "Likely" meaning "will it fold differently within that cell type more often than it might misfold otherwise."

If there is a difference in the way proteins are folded between different types of cells, is there any relatively comprehensive list of the differences and members of different groups of protein folding/misfolding mechanics?

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