Re: [DIYbio] "DIY Human CRISPR" by Josiah Zayner

Theoretically you could get the Cas-9 / CRISPR system to be introduced systemically in the human system if you used a hepadnavirus or lenitvirus that has the Cas-9 protein (or the nucleic cassette for it) and desired targeting sequence all packaged into the viral vector. 

I think it's probably better to think of removing genetic diseases from the population (Huntington's disease, Non-Hodgkin's lymphoma, etc.) at an egg (single cell) level then to start playing with the idea of altering an entire human system just because of some "Snaggle [teeth]" or because you think you lost the "genetic lottery" based on some arbitrary physical traits. 

-SG 

On Thu, Oct 12, 2017 at 8:34 AM, John Griessen <john@industromatic.com> wrote:

On 10/12/2017 04:17 AM, 'Lisa Thalheim' via DIYbio wrote:

The first thing that jumps out at me: He grossly misrepresents the
technical difficulty of (DIY) human CRISPR, apparently for the sake of a
"cool" narrative.

I think he was talking in the realm of possibilities, so difficult is definitely possible,
so he probably has triggered some thinking on this by some people who heard him.
What-if? kind of thinking, and by the time some of the audience consider action, the difficulty
of some steps may be much less.  A "cool" narrative is going to be heard by young people more
than a dry narrative, so it's all fine by me as far as free speaking and idea generating goes.
I doubt anyone inspired by this to dig deeper will feel cheated when they find the steps
involving CAS9 are tricky with negative side effects...

Instead, they will probably think, "How would you do the same as CAS9 without such negatives?"

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