Re: [DIYbio] Twins get 'mystifying' DNA ancestry test results (Marketplace) CBC Documentary

6:06 AM |

I'm kinda curious whether people are genuinely shocked by this. (or am I doing the typical mind thing)

discordance of ~2K snps between them  implies fairly crappy chips.
kinda wondering how much pivots on snps that often don't read well.

They probably should calibrate predictions including knocking out SNPs on a level similar to expected concordance and ensure that random knockout doesn't significantly change predictions.

It's possible to do some cool stuff in real research: I've had cases where I've needed to deal with samples from a single village. As part of QC we use PCA to make sure cases cluster with controls  and some samples from a hundred miles down the road that shouldn't have been included in the set given to me stood out like a sore thumbs.




On Sat, Feb 2, 2019 at 1:30 PM Cabalen sciences <ryangavieres123@gmail.com> wrote:
https://www.youtube.com/watch?v=Isa5c1p6aC0

This segment is on how genome sequencing operates and how DNA sampling is examined. 


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