Re: [DIYbio] Twins get 'mystifying' DNA ancestry test results (Marketplace) CBC Documentary

Well, this paper by Michael Lynch indicates otherwise. https://www.pnas.org/content/107/3/961

Note the fourth paragraph under the heading "Cumulative Burden of Somatic Mutations" in the Discussion section:

"Assuming 1.5% coding DNA, these somatic rates roughly translate into approximately 100 to 1,000 mutations per nonreplicating diploid cell at the age of maturity and approximately 10^3 to 10^4 per replicating cell."

I would guess that epithelial cells from a buccal swab or WBCs from blood would both qualify as cells that are derived from a relatively high number of replications, so would likely be in the 1000-10,000 mutations/cell group.

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