Re: [DIYbio] Twins get 'mystifying' DNA ancestry test results (Marketplace) CBC Documentary

eh, twins typically vary by something like 100 to 200 bases... ish

Those SNP chips only sample 700k out of 3 billion bases so the odds of even one real difference between twins being real are pretty poor.

Though normal individuals vary almost as much as twins within their own tissues, take samples of blood, skin, brain, liver etc from the same individual and you'll get a few dozen real variants between the tissues.

On Sat, Feb 9, 2019 at 6:23 PM 'qetzal' via DIYbio <diybio@googlegroups.com> wrote:

Sandwalk has a good post on this. See https://sandwalk.blogspot.com/2019/01/what-happens-when-twins-get-their-dna.html .

Bottom line, identical twins don't have completely identical DNA. In fact, none of us do. If you could completely sequence two different cells from different parts of your body, there would be differences that accumulated during cell division.

However, if the Sandwalk post is correct, the twin comparison was affected mainly by small errors in the test, not because of the true but rare actual differences between the twins' DNA.

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