Re: [DIYbio] Re: Drug addiction biohacking

I'll be blunt and say that to me this looks like a dead end, as far as a practical route. The research you linked was (going by the abstract at least) only examining one system, and cannot have gathered enough data on the other systems or the broader effects to rule out harm.

Even their own abstract ends with: "We suppose that the effect of microwaves is related to the stress reactions of the organism."

This might mean a mild and localised heat stress, or microwave-induced blood-brain-barrier leakage and consequent inflammation, or an increase in ROS and radical formation or misfolding due to enzyme damage. All are possible outcomes IMO from a blanket application of energising radiation.

I would be on the side of preferring social routes to solving addiction epidemics: basic income shows promise, better regulation of drug marketing and decriminalisation/medicalisation seem to be good policies, and there is research into older/newer pharmacological interventions pike psychedelic therapy.

But if a "medicalised silver bullet" is the goal then my money would be on small molecules in this case, as the medicine needs to cross the BBB and temporary antagonism of the right systems might be the simplest way to support behavioural therapies.

But then.. we've been there for years already and have few success stories so far.

On 24 September 2019 01:51:36 GMT+01:00, jackson parks <jacksonpar...@gmail.com> wrote:

I'll show what I'm referring to:

https://www.ncbi.nlm.nih.gov/pubmed/8962884

On Monday, September 23, 2019 at 7:50:36 PM UTC-4, Cathal Garvey wrote:

I'm no biophysicist but.. I'm finding it hard to imagine a way to use microwaves to reliably target only a single protein or conjugate. Even with a mythological control over frequency and amplitude, I'm assuming there would be a very diverse set of proteins and such that would absorb some of it, not to mention the background water and other small molecules?

On 23 September 2019 20:22:36 GMT+01:00, jackson parks <jacksonpar...@gmail.com> wrote:

Well the bottom line is, we're looking to experiment with switching off the GABA receptor's capacity to allow xenobiotic agonists to bind to them, also looking to do this with things like microwaves. We need to have the capacity to shut off only the parts of things like GABA and NMDA to disallow certain chemicals to be agonists/antagonists for them. This doesn't involve warfare, there are some people who are too addicted for rehab or anything similar to do anything for them. We're looking to go into the nervous system and actually shut off parts of the CNS so that drugs can't do anything to them - and we want a way to reverse the process to reestablish everything after they have recovered. I know this is radical, and I'm not familiar with anyone who's accomplished this, but hopefully this gets some sort of a ball rolling.

On Monday, September 23, 2019 at 2:49:21 PM UTC-4, Chris Santos-Lang wrote:

I am worried that applying biology to drug addiction is like applying nuclear fission to warfare. Drug addiction and war are social problems, not biological or physical problems, so bringing in biology and physics really just escalates the arsenal.

How's about applying science to analyze and correct the social problem?

Best Wishes,

Chris Santos-Lang

On Mon, Sep 23, 2019 at 3:27 AM Darlene Aldente <darlene...@gmail.com> wrote:

Check out D-Cycloserine. a search of "d-cycloserine and addiction" in pub med or google scholar will give you a ton of recent peer reviewed articles. This is an old tuberculosis antibiotic that has been discovered to act on the glutamate receptor int the brain which is central to the neuroplasticity disruption associated with addition. It has shown real results when combined with CBT and the CBT sessions are times with ingestion of the drug. Same method has shown great results for war related PTSD. because the drug increases neuroplasticity, and for other reasons, it has a measurable positive effect on learning (if only I had this drug in college). You Do NOT need to take the full tuberculosis dose, just half. Also, I'm not sure about the duration of treatment.

There is one BIG problem however: the cost. This drug has recently fallen prey to opportunistic "investors."  in 2015 the price of cycloserine increased from $500 for 30 pills to $10,800 Rodelis Therapeutics purchased it. Purdue University, the previous owner, which retained "oversight of the manufacturing operation" intervened and Rodelis returned the drug to an NGO of Purdue University foundation whi8ch now charges $1,050 for 30 capsules. If you discover a way to use the NGO system through wich governments and non-profits obtain the drug for a fraction of the price please let us know!!

On Thursday, September 19, 2019 at 5:40:44 PM UTC-4, jackson parks wrote:

Hello,

Thank you for letting me in. I'm Jack. A friend of mine named Jonathyn recently quit the idea of engaging in CRISPR CAS9 technology because he found out that it can't do anything for adult humans. We've been trying to find a way to help people with drug addiction, and we got introduced to biohacking. We're interested in being able to change people's nervous systems either through microwave radiation (https://www.ncbi.nlm.nih.gov/pubmed/1312845), CRISPR (if it can do anything at all), or whatever other means that don't technically need surgical procedures.

Thank you all, Jack.

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