Coronavirus disease 2019 (COVID-19) is newly emerging human infectious diseases, which is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, also previously known as 2019-nCoV). Within two months of the outbreak, more than 80,000 cases of COVID-19 have been confirmed worldwide. Since the human to human transmission occurred easily and the human infection is rapidly increasing, the sensitive and early diagnosis is essential to prevent the global outbreak. Recently, World Health Organization (WHO) announced various primer and probe sets for SARS-CoV-2 previously developed in China, Germany, Hong Kong, Japan, Thailand, and USA. In this study, we compared the ability to detect SARS-CoV-2 RNA among the seven primer-probe sets for N gene and the three primer-probe sets for Orf1 gene. The result of the comparative analysis represented that the '2019-nCoV_N2, N3' of USA and the 'ORF1ab' of China are the most sensitive primer-probe sets for N and Orf1 genes, respectively. Therefore, the appropriate combination from ORF1ab (China), 2019-nCoV_N2, N3 (USA), and NIID_2019-nCOV_N (Japan) sets should be selected for the sensitive and reliable laboratory confirmation of SARS-CoV-2.
Would someone post the datasheet(s) of the existing biopharma tests?
There have been various news reports of commercial test failures.
Quote from news a few weeks ago: "It remains unclear whether the CDC's
move on Wednesday will resolve all of the problems around the test.
Some local labs have raised concerns about whether the CDC's test is
fully reliable for detecting COVID-19. In New York, scientists at
both the city's and state's laboratories have seen false positives
even when following the CDC's latest directions, according to a person
familiar with their discussions."
An erroneous test result can probably be shown to be worse than having
no result at all. I am sure diybio will forge ahead independent of
that.
On 3/4/20, AJP <bioajp@gmail.com> wrote:
> tl, dr; if you get a DIY positive result I think that's useful, if it's
> negative then assuming everything else is equal you're in no different
> position to everyone else who hasn't been tested.
>
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