Hi Frank,
Yes this study is quite intriguing, but they did not use a global test to quantify the systemic rejuvenation, so it is hard to evaluate exactly what happened. That's why I want to use an epigenetic age test. Yes, those are fancy and quite expensive (starts at 300 usd/ test with the cheapest provider), but they are the gold standard to measure biological age, and thus evaluate more precisely how effective the procedure is. You can read about epigenetic clocks here: https://nintil.com/epigenetic-clocks
I don't think you could remove blood and replace orally by saline. I don't have good evidence for or against but I wouldn't try it. Anyone else knows more about it?
Regarding blood donation yes plasma donation is the closest you can come with. I don't have access to that in the UK (you can only give whole blood or platelets). In the US it's even better than free you're paid a little for it, I think, and you can give plasma twice a week. If you do it, it would be great if you were able to be able to quantify the effect a bit. I'm not sure a whole epigenetic test is worth it though; if it were really that powerful, we would have noticed. Or maybe there is a threshold effect somehow where 25 is not enough to trigger whatever it is that happens?
Anyway, keep us updated.
On my side I will try to find a clinic and MD to do it, or worst case organize a small clinical trial. Or we might as well wait for the UC Berkeley team to complete their own clinic trial :)
Best regards,
On Sun, 28 Jun 2020 at 05:17, Frank <fgarcia0007@gmail.com> wrote:
Hi Raphael,An epigenetic age test sounds pretty sophisticated. would love to learn more about that. Is it a standard lab test I can order?I'm in New York City. I learned a little more about doing this which opened up an unexpected avenue and more questions1. Since the discovery and validation of young blood transfusion rejuvenation efficacy, studies like the recent UC Berkeley paper figured out that the effect comes less from gaining systemic factors in the young blood than from loosing detrimental factors in the old blood.2. The key to the rejuvenating effect of the therapeutic plasma exchange TPE/plasmapheresis is eliminating 50% (less is Ok though not optimal) of the older subject's plasma. Plasma constitutes around 60% of total blood volume, so removing 50% means 30% of total blood volume. For my size that equals about 3.4 liters!!. That would result in potentially catastrophic blood pressure drop so it has to be replaced by isotonic saline and it has to be done incrementally if you don;t have a continuous centrifugal separation apheresis machine which is very pricey.3. One question I have is if the saline can be taken orally? would the body not absorb the solution just the same as intravenously albeit more slowly?Thus doing this myself is out of the question. I would need at least one other well-trained person present. in looking around for labs or service providers that offer TPE I stumbled upon blood donation. When you dontse blood nowadays you get choose the type of donation: Whole blood, RBC only, Plasma, or platelet. Well sure enough the way the blood bank takes a plasma donation is by using plasmapheresis, ha! So by donating plasma you get a rejuvenation treatment for free. The main drawback is that they only take a pint of plasma which is about half of the optimal 50%. So I am scheduled to do this early next week.--On Saturday, June 27, 2020 at 3:06:04 PM UTC-4 Raph N wrote:Hi Frank,Great minds think alike, I'd love to test that, especially with an epigenetic age test to quantify the rejuvenation potential.
Where about are you?
I'm in the UK.
Raphael
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