That's true enough about commercial test, though there's an easy way to check their validity: Don't give the company your age, and see how accurate the results are.
However I still believe that in principle epigenetic age are the best marker for age. That it is hard to test doesn't change the results. In fact, if you want to be accurate, you can contact Steve Horvath and get his help for the testing. That's what I'm working on for stem cells and exosomes with a few test patients.
Cheers
On Tue, 30 Jun 2020 at 17:41, James Clement <clementlawyer@gmail.com> wrote:
--Proprietary tests that haven't been validated independently (peer-reviewed and duplicated in other labs) are nice tools for doctors to convince their patients that whatever they're doing is working, but aren't useful scientifically. The same is true of cheap telomere tests, or other purported proprietary biomarkers, IMHO.
Cheers,
James
On Monday, June 29, 2020 at 7:55:58 PM UTC-4, Gary Dale wrote:I am in my 60's and am considering donating plasma or blood also but want to try and verify if there is any rejuv. I am looking into epigenetic age tests that are available to run BEFORE donating and then after some number of donations.This is my first day researching it but this kit seems interesting and not too expensive.
On Monday, June 29, 2020 at 2:10:05 PM UTC-5, Frank wrote:James,Thanks for the response. I am actually close to 60. Unless I find a plasmapheresis machine for free I will likely not attempt this myself mainly due to the impracticality of extracting the amount of plasma needed manually/incrementally. I actually have an educational background in medicine though I am not a practicing physician. The avenue that I thought might be useful is donating plasma which amounts to a TPE treatment though the volume taken is still inadequate. I had bad luck trying that yesterday as I was turned away for not having an AB blood type. After looking into it I was told this was a mistake and that I should be able to donate so I will try again next week. If you are looking for trial subjects by all means sign me up.On Monday, June 29, 2020 at 2:04:44 PM UTC-4 James Clement wrote:Betterhumans has been looking at running an IRB-approved clinical trial using TPE for several years (we have run a half-dozen different antiaging clinical trials since 2016 and intend to run about eight in 2021). I was part of a small group that approached Dr Dobri Kiprov in 2014 to arrange for a TPE clinical trial, but he wanted $25,000 per patient for a single treatment. We have since done a lot more research on recurring TPE therapy and believe we can do far more cheaply than this, but there are lots of potential risks and side effects if you try to do it too frequently. Since Betterhumans is opening its own antiaging clinical trial medical office in the near future with our own medical staff, we have been waiting until it is operational to pursue this particular clinical trial further. Of course the latest Conboy paper only strengthened our desire to test this in elderly subjects, when we are set up to proceed. We also have all of the analytical instruments in our laboratory to determine whether it works (including an Illumina iScan sequencer to run Infinium 800k beadchips, the only validated method for the Horvath clocks, with whom we're collaborating).I don't know you or the others who have responded to this personally, but assuming you are not in your mid 60s or older, I would highly recommend that you do not attempt to DIY this yourself. If you're under 50 then you have plenty of time to wait for multiple clinical trials to prove the real-life efficacy and safety of TPE for antiaging purposes, and work the kinks out. We are finding there are downsides and risks to all of the antiaging therapies we have tested so far, and at least for the time being they should be reserved for those who simply can't wait the 10 years or more for them to be properly tested and optimized.
Best regards,
James
On Saturday, June 27, 2020 at 1:42:46 AM UTC-4, Frank wrote:Recent published experiments like the one below from UC Berkeley, demonstrate multi-system rejuvenation from an existing widely available procedure, therapeutic plasma exchange TPE. This is quite exciting and the paper is well worth reviewing. I am interested in begin able to perform TPE on myself with someone's help. If you are interested please let me know.
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