Quantitatively and qualitatively how do the benefits demonstrated in the 50% plasma dilution experiment compare with changes observed after anti-senescence therapy (senolytics) that wipe out populations of senescent cells?
What, if any, of the systemic factors (peptides) reduced in plasma dilution via TPE, are the same as those secreted by senescent cells that define the senescent secretory phenotype?
Do senolytics attack the source of the factors that are reduced in plasma dilution and which reduction results is "rejuvenating" effects?
Are young blood transfusion, plasma dilution and senotherapeutics essentially antagonizing the same process?
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