Re: [DIYbio] Re: Is BioBricks Free Genes Project still maintained and alive?

molecular cloning in itself as a molecular biology technique is automatically regarded to some/most as 'biobricks' activity but its use far predates the synthetic biology movement

On Tue, Dec 27, 2022 at 12:13 PM Dan Kolis <dankolis@gmail.com> wrote:
Is this summary correct ?

" The aspiration of many people in bio sciences that electronics provides macro concepts useful for application of nucleotide sequences is essentially incorrect. "

" These notions, ( that simplify life processes ),  cannot be excised from viable life systems, including chaperones, post translation mRNA edits, long standing methylization attachments, and literally hundreds of biological effects implemented in life as built by Mother nature, in everything alive. "

Finally: "The reused terminology and desire to make VLSI like IDE's, ---may be useful in development of synthetic biology, but it appears this is almost simply a dead end. "

Is this possibly correct ? 

Regards,
Daniel B. Kolis

PS I saw paper saying the actual wet-lab attempts with BioBricks DB plopped into glassware had a success rate by the applicable goals of each project of around 2%. My belief system is that is not zero... But the notion itself needs a full scale downgrade from first principles. What replaces it is: MORE USUAL HARD WORK AND NEW IDEAS ENTIRELY.

what do you think ?

Daniel B. Kolis



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