In my personal experience everyone I met started with or became interested in the DIYBio movement from a place of passion and creative curiosity. The DIY aspect was attractive to me because, not everyone gets invited inside the ivory tower of academia or has access to R1 schools and labs. Just because you aren't a mechanic for a NASCAR or Formula 1 team doesn't mean you can't buy a junk car and some tools and tinker in your garage.
To me DIYBio was allowing access to "do science" outside of the normal places you do science. What you're able to learn should be delinked from age and resources, though it often isn't. Doing science is expensive. The tools are expensive, the reagents are expensive, and proper space is expensive. Over time that bleeds you dry. And yes, I know it can be done "on the cheap".
The "open" aspect of sharing went away after taking investor money in my case. And then once you can no longer live at your parents, bills start piling up to live, and hobbies generally don't pay the bills. So you grow up and get a job and have less time to tinker for the sake of it. Big props to the people that were able to make viable businesses, if even for short periods of time, in this space.
I met some amazing people in person and online from this list and still keep in touch with a number of them!
On Tue, May 19, 2026 at 10:16 AM Hans <hanstwilms@gmail.com> wrote:
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That's the DIYBio discord. It's more active than this, but not very.What were you trying to do with DIYbio? I wanted to manufacture super cheap enzymes for other DIYBio people. It was Keoni doing the FreeGenes stuff, but I think that's dead too.
What do you guys think killed the DIYbio movement?
-Hans Wilms
On Mon, May 18, 2026, 8:10 PM Dakota Hamill <dkotes@gmail.com> wrote:
Very cool piece of open hardware and nice documentation. Electrical engineering seems to be where open source shines.
--On Fri, May 15, 2026 at 10:01 PM S James Parsons Jr <sjamesparsonsjr@gmail.com> wrote:
opulo LumenPnP--
On May 14, 2026, at 7:19 PM, Dakota Hamill <dkotes@gmail.com> wrote:
Has anyone come across any case studies of businesses that have adhered to the open source model and shared all the nitty gritty details of creating, manufacturing, pricing, and selling an open source product for a profit?
I came across an interesting talk a while back
Which was then followed by someone who wrote a book on the topicOpen Hardware Basics and Business Alicia Gibb
I know Adafruit and Sparkfun have done pretty well, but it seems like open source fits well with electrical engineering. Arduino is now closed source? MakerBot was a big one in the early days to go closed once they took money.
This open source bioreactor is cool and is the type of product I'd be interested in seeing a case study on. https://pioreactor.com
More interested in the science-hardware side of things but wondering of any other examples I've not been able to find. Seems like there's a lot of individual projects but very few "DIYBio" style companies at the size/scale of AdaFruit or Sparkfun.
I get that transistors are much cheaper and easier to store than enzymes.
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